Journal ArticleDOI
Large-Pore Mesoporous-Silica-Coated Upconversion Nanoparticles as Multifunctional Immunoadjuvants with Ultrahigh Photosensitizer and Antigen Loading Efficiency for Improved Cancer Photodynamic Immunotherapy
Binbin Ding,Binbin Ding,Shuai Shao,Shuai Shao,Chang Yu,Bo Teng,Meifang Wang,Meifang Wang,Ziyong Cheng,Ka-Leung Wong,Ping'an Ma,Jun Lin +11 more
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TLDR
Large‐pore mesoporous‐silica‐coated upconversion nanoparticles (UCMSs) with a size of less than 100 nm are successfully prepared by a typical silica sol–gel reaction using mesitylene as a pore‐swelling agent and applied as a novel immunoadjuvant, suggesting the enhanced immunotherapy efficacy and clinical potential of UCMSs as immunoad Juvant for cancer immunotherapy.Abstract:
Reported immunoadjuvants still have many limitations, such as inferior cellular uptake capacity and biocompatibility, overly large particle sizes, single function, and unsatisfactory therapeutic efficacy. Here, large-pore mesoporous-silica-coated upconversion nanoparticles (UCMSs) with a size of less than 100 nm are successfully prepared by a typical silica sol-gel reaction using mesitylene as a pore-swelling agent and are applied as a novel immunoadjuvant. The obtained UCMSs not only show significantly higher loadings for the photosensitizers merocyanine 540 (MC540), model proteins (chicken ovalbumin (OVA)), and tumor antigens (tumor cell fragment (TF)), but also are successfully employed for highly efficient in vivo vaccine delivery. The prepared UCMSs-MC540-OVA under 980 nm near-infrared irradiation shows the best synergistic immunopotentiation action, verified by the strongest Th1 and Th2 immune responses and the highest frequency of CD4+ , CD8+ , and effector-memory T cells. Additionally, nanovaccines UCMSs-MC540-TF can more effectively inhibit tumor growth and increase the survival of colon cancer (CT26)-tumor-bearing BALB/c mice compared with either photodynamic therapy or immunological therapy alone, suggesting the enhanced immunotherapy efficacy and clinical potential of UCMSs as immunoadjuvants for cancer immunotherapy.read more
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Journal ArticleDOI
Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications
TL;DR: The representative progresses of MONs on synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, and therapy are mainly introduced.
Journal ArticleDOI
A Mesoporous Nanoenzyme Derived from Metal-Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy.
Dongdong Wang,Huihui Wu,Wei Qi Lim,Soo Zeng Fiona Phua,Pengping Xu,Qianwang Chen,Zhen Guo,Yanli Zhao +7 more
TL;DR: An interesting biomedical use of MOF‐derived mesoporous NE derived from metal–organic frameworks is presented for in situ generation of endogenous O2 to enhance the PDT efficacy under bioimaging guidance.
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NIR-Triggered Phototherapy and Immunotherapy via an Antigen-Capturing Nanoplatform for Metastatic Cancer Treatment
Meng Wang,Jun Song,Feifan Zhou,Ashley R. Hoover,Cynthia K. Murray,Benqing Zhou,Lu Wang,Junle Qu,Wei R. Chen +8 more
TL;DR: The synergized photothermal, photodynamic, and immunological effects using light‐activated UCNP/ICG/RB‐mal induces a tumor‐specific immune response and provides a promising approach for the treatment of metastatic cancers.
Journal ArticleDOI
MnOx Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect.
Binbin Ding,Binbin Ding,Pan Zheng,Fan Jiang,Fan Jiang,Yajie Zhao,Yajie Zhao,Meifang Wang,Meifang Wang,Mengyu Chang,Mengyu Chang,Ping'an Ma,Ping'an Ma,Jun Lin,Jun Lin +14 more
TL;DR: MnOx nanospikes (NSs) as tumor microenvironment (TME)-responsive nanoadjuvants and immuogenic cell death (ICD) drugs are proposed firstly for cancer nanovaccine-based immunotherapy and can not only achieve TME-responsive magnetic resonance/photoacoustic dual-mode imaging contrasts, but also effectively inhibit primary/distal tumor growth as well as tumor metastasis.
Journal ArticleDOI
Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release.
Sheng Wang,Sheng Wang,Guocan Yu,Zhantong Wang,Orit Jacobson,Lisen Lin,Weijing Yang,Hongzhang Deng,Zhimei He,Yuan Liu,Zhi-Yi Chen,Xiaoyuan Chen +11 more
TL;DR: In vivo results indicate that the cascade of ROS generation and anti-tumor drug release can effectively inhibit tumor growth, and this design of nanomedicine with cascade reactions offers a promising strategy to enhance anti-Tumor efficacy.
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