LDL particle number and risk of future cardiovascular disease in the Framingham Offspring Study—Implications for LDL management

doi:10.1016/J.JACL.2007.10.001

Open AccessJournal ArticleDOI

LDL particle number and risk of future cardiovascular disease in the Framingham Offspring Study—Implications for LDL management

William C. Cromwell, +7 more

- 01 Dec 2007 -

Journal of Clinical Lipidology

- Vol. 1, Iss: 6, pp 583-592

Chats0

TLDR

In a large community-based sample, LDL-P was a more sensitive indicator of low CVD risk than either LDL-C or non-HDL-C, suggesting a potential clinical role for LDL-p as a goal of LDL management.

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This article is published in Journal of Clinical Lipidology.The article was published on 2007-12-01 and is currently open access. It has received 409 citations till now. The article focuses on the topics: Low-density lipoprotein particle & Framingham Risk Score.

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References

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Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

William T. Friedewald, +2 more

- 01 Jun 1972 -

Clinical Chemistry

TL;DR: A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.

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Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Scott M. Grundy, +27 more

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JAMA

TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.

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Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines

Scott M. Grundy, +8 more

- 13 Jul 2004 -

Circulation

TL;DR: The trials confirm the benefit of cholesterol-lowering therapy in high-risk patients and support the ATP III treatment goal of low-density lipoprotein cholesterol (LDL-C) <100 mg/dL, and confirm that older persons benefit from therapeutic lowering of LDL-C.

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MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Commentary

Salim Yusuf

- 01 Jan 2002 -

The Lancet

TL;DR: Adding simvastatin to existing treatments safely produces substantial additional benefits for a wide range of high-risk patients, irrespective of their initial cholesterol concentrations.

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Journal ArticleDOI

An investigation of coronary heart disease in families the framingham offspring study

William B. Kannel, +4 more

- 01 Sep 1979 -

American Journal of Epidemiology

TL;DR: There is little evidence that coronary heart disease (CHD) experience and CHD risk factors differ in parents of those who volunteered for this study and the parents ofThose who did not volunteer.

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