Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication
Kathleen R. Merikangas,Hagop S. Akiskal,Jules Angst,Paul E. Greenberg,Robert M. A. Hirschfeld,Maria Petukhova,Ronald C. Kessler +6 more
TLDR
This study presents the first prevalence estimates of the BPD spectrum in a probability sample of the United States, and finds subthreshold BPD is common, clinically significant, and underdetected in treatment settings.Abstract:
The estimated lifetime prevalence of bipolar disorder (BPD) in population surveys using structured diagnostic interviews and standardized criteria averages approximately 0.8% for BP-I and 1.1% for BP-II.1-8 Despite this comparatively low prevalence, BPD is a leading cause of premature mortality due to suicide and associated medical conditions such as diabetes and cardiovascular disease.9, 10 BPD also causes widespread role impairment.11, 12 The recurrent nature of manic and depressive episodes often leads to high direct as well as high indirect health care costs.13, 14
BPD might be even more burdensome from a societal perspective due to the fact that sub-threshold bipolar spectrum disorder has seldom been taken into consideration in examining the epidemiology of BPD. Bipolar spectrum disorder includes hypomania without major depression and hypomania of lesser severity or briefer duration than specified in the DSM and ICD criteria. Although the precise definitions are as yet unclear, recent studies suggest that bipolar spectrum disorder might affect as many as 6% of the general population.15, 16 However, bipolar spectrum disorder has not been studied previously in a nationally representative survey of the US. The purpose of the current report is to present the results of such a study based on analysis of the National Comorbidity Survey Replication (NCS-R).17 We estimate prevalence and clinical features of sub-threshold BPD in comparison to BP-I and BP-II.read more
Citations
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Journal ArticleDOI
Bipolar spectrum in major depressive disorders.
Jules Angst,Kathleen R. Merikangas,Lihong Cui,A Van Meter,A Van Meter,Vladeta Ajdacic-Gross,Wulf Rössler,Wulf Rössler,Wulf Rössler +8 more
TL;DR: The clinical correlates of those with the subthreshold manic syndrome were more similar to those with bipolar-II disorder than toMDD alone, whereas those with manic symptoms only were intermediate between those with subth threshold manic syndrome and MDD alone.
Journal ArticleDOI
The relationship of manic episodes and drug abuse to sexual risk behavior in patients with co-occurring bipolar and substance use disorders: a 15-month prospective analysis.
Christina S. Meade,Garrett M. Fitzmaurice,Garrett M. Fitzmaurice,Amy K. Sanchez,Margaret L. Griffin,Margaret L. Griffin,Leah J. McDonald,Roger D. Weiss,Roger D. Weiss +8 more
TL;DR: It is suggested that bipolar patients with active and/or recurrent mania are in need of targeted HIV prevention services and individual differences in impulsivity may explain the association between mania and sexual risk.
Journal ArticleDOI
Lithium in late-life mania: A systematic review
Pasquale De Fazio,Raffaele Gaetano,Mariarita Caroleo,Maria Pavia,Giovanbattista De Sarro,Andrea Fagiolini,Cristina Segura-Garcia +6 more
TL;DR: Evidence suggests that lithium is effective and tolerated in this subgroup of patients and thus should remain a first-line drug, and seems to be more effective at lower doses and close monitoring of plasma concentrations is necessary.
Journal ArticleDOI
Memantine as an Adjuvant Treatment for Obsessive Compulsive Symptoms in Manic Phase of Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
TL;DR: It is shown that memantine is an effective adjuvant agent for reducing OC symptoms in patients with BD, however, it needs to be noted that this study is preliminary, and larger double-blind controlled studies are needed to confirm the results.
Journal ArticleDOI
The increasing frequency of mania and bipolar disorder: causes and potential negative impacts.
TL;DR: The frequency of mania has not changed during the last century even with the development of new diagnostic criteria sets, and explanations for this change are reviewed and the potentially negative impacts on the field are reviewed.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
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Journal ArticleDOI
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