Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication
Kathleen R. Merikangas,Hagop S. Akiskal,Jules Angst,Paul E. Greenberg,Robert M. A. Hirschfeld,Maria Petukhova,Ronald C. Kessler +6 more
TLDR
This study presents the first prevalence estimates of the BPD spectrum in a probability sample of the United States, and finds subthreshold BPD is common, clinically significant, and underdetected in treatment settings.Abstract:
The estimated lifetime prevalence of bipolar disorder (BPD) in population surveys using structured diagnostic interviews and standardized criteria averages approximately 0.8% for BP-I and 1.1% for BP-II.1-8 Despite this comparatively low prevalence, BPD is a leading cause of premature mortality due to suicide and associated medical conditions such as diabetes and cardiovascular disease.9, 10 BPD also causes widespread role impairment.11, 12 The recurrent nature of manic and depressive episodes often leads to high direct as well as high indirect health care costs.13, 14
BPD might be even more burdensome from a societal perspective due to the fact that sub-threshold bipolar spectrum disorder has seldom been taken into consideration in examining the epidemiology of BPD. Bipolar spectrum disorder includes hypomania without major depression and hypomania of lesser severity or briefer duration than specified in the DSM and ICD criteria. Although the precise definitions are as yet unclear, recent studies suggest that bipolar spectrum disorder might affect as many as 6% of the general population.15, 16 However, bipolar spectrum disorder has not been studied previously in a nationally representative survey of the US. The purpose of the current report is to present the results of such a study based on analysis of the National Comorbidity Survey Replication (NCS-R).17 We estimate prevalence and clinical features of sub-threshold BPD in comparison to BP-I and BP-II.read more
Citations
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Journal ArticleDOI
Increased depressive symptoms in menopausal age women with bipolar disorder: age and gender comparison.
TL;DR: The course of bipolar disorder focusing on depressive symptoms in menopausal transition age women, compared to similar-aged men as well as younger adult women and men are examined to better inform clinical practice in treating women with bipolar disorder.
Journal ArticleDOI
The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder
Georg Riemann,Nadine Weisscher,Robert M. Post,Lori L. Altshuler,Susan L. McElroy,Marc A. Frye,Paul E. Keck,Gabriele S. Leverich,Trisha Suppes,Heinz Grunze,Willem A. Nolen,Ralph W. Kupka +11 more
TL;DR: Having more BPF at baseline is associated with a higher episode frequency during subsequent 1-year follow-up, and affective instability, impulsivity, and self-mutilation/suicidality are associated with both rapid cycling BD and BPD.
Journal ArticleDOI
Under-reporting bipolar disorder in large-scale epidemiologic studies
Elie G. Karam,Nancy A. Sampson,Lynn Itani,Laura Helena Andrade,Guilherme Borges,Wai Tat Chiu,Silvia Florescu,Itsuko Horiguchi,Zahari Zarkov,Hagop S. Akiskal +9 more
TL;DR: A revision of instruments used in epidemiologic research will probably prove what clinical studies have been showing that bipolar disorder is more common than has been reported.
Journal ArticleDOI
Editorial: Back to the Future: On the Road Towards Precision Psychiatry.
Brisa Simoes Fernandes,Stefan Borgwardt,Stefan Borgwardt,Andre F. Carvalho,Andre F. Carvalho,Johann Steiner +5 more
TL;DR: This research presents a novel and scalable approach to personalized medicine that addresses the major barriers to effective and efficient treatment of mental and physical illness in patients with a history of substance abuse.
Journal ArticleDOI
Safety and Efficacy of Quetiapine in Bipolar Depression
Gregory T Bogart,Benjamin Chavez +1 more
TL;DR: Clinical data demonstrated quetiapine's efficacy in the treatment of depressive phases of bipolar disorder, including statistically significant improvement in the Montgomery-Åsberg Depression Rating Scale (MADRS).
References
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