Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication
Kathleen R. Merikangas,Hagop S. Akiskal,Jules Angst,Paul E. Greenberg,Robert M. A. Hirschfeld,Maria Petukhova,Ronald C. Kessler +6 more
TLDR
This study presents the first prevalence estimates of the BPD spectrum in a probability sample of the United States, and finds subthreshold BPD is common, clinically significant, and underdetected in treatment settings.Abstract:
The estimated lifetime prevalence of bipolar disorder (BPD) in population surveys using structured diagnostic interviews and standardized criteria averages approximately 0.8% for BP-I and 1.1% for BP-II.1-8 Despite this comparatively low prevalence, BPD is a leading cause of premature mortality due to suicide and associated medical conditions such as diabetes and cardiovascular disease.9, 10 BPD also causes widespread role impairment.11, 12 The recurrent nature of manic and depressive episodes often leads to high direct as well as high indirect health care costs.13, 14
BPD might be even more burdensome from a societal perspective due to the fact that sub-threshold bipolar spectrum disorder has seldom been taken into consideration in examining the epidemiology of BPD. Bipolar spectrum disorder includes hypomania without major depression and hypomania of lesser severity or briefer duration than specified in the DSM and ICD criteria. Although the precise definitions are as yet unclear, recent studies suggest that bipolar spectrum disorder might affect as many as 6% of the general population.15, 16 However, bipolar spectrum disorder has not been studied previously in a nationally representative survey of the US. The purpose of the current report is to present the results of such a study based on analysis of the National Comorbidity Survey Replication (NCS-R).17 We estimate prevalence and clinical features of sub-threshold BPD in comparison to BP-I and BP-II.read more
Citations
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Journal ArticleDOI
Post-traumatic stress burden in a sample of hospitalized patients with Bipolar Disorder: Which impact on clinical correlates and suicidal risk?
Claudia Carmassi,Carlo Antonio Bertelloni,Valerio Dell'Oste,Claudia Foghi,Elisa Diadema,Annalisa Cordone,Virginia Pedrinelli,Liliana Dell'Osso +7 more
TL;DR: The findings show a history of multiple traumatic experiences in hospitalized patients with BD besides high rates of PTSD, with the co-occurrence of these conditions appearing to be related to a more severe BD.
Journal ArticleDOI
Possible New Ways in the Pharmacological Treatment of Bipolar Disorder and Comorbid Alcoholism
Jean-Michel Azorin,Charles L. Bowden,Ricardo P. Garay,Giulio Perugi,Eduard Vieta,Allan H. Young +5 more
TL;DR: Clinical trials in bipolar patients with comorbid alcoholism of the last four years were reviewed to provide guidelines for possible use of valproate and other agents in patients with a dual diagnosis of bipolar disorder and substance abuse or dependence.
Journal ArticleDOI
Evidence for the continuous latent structure of mania in the Epidemiologic Catchment Area from multiple latent structure and construct validation methodologies
TL;DR: Whether mania has a continuous or discrete latent structure using a comprehensive approach including taxometric, information-theoretic latent distribution modeling (ITLDM) and predictive validity methodologies in the Epidemiologic Catchment Area (ECA) study is examined.
Journal ArticleDOI
Impaired functioning in euthymic patients with bipolar disorder — HSV-1 as a predictor
S. Gerber,Ute J Krienke,Nane C. Biedermann,Heinz Grunze,Robert H. Yolken,Sandra Dittmann,Jens M. Langosch +6 more
TL;DR: Findings confirm previous findings suggesting that HSV-1 affects cognitive functions in patients with bipolar disorder, which may also result in more impaired functioning, less quality of life and difficulties in social adjustment.
Journal ArticleDOI
The effect of comorbid anxiety disorder on neuropsychological function in bipolar II disorder
Hsin I. Wu,Yun Hsuan Chang,Chun Chieh Lai,Jo Yung Wei Wu,Shiou Lan Chen,Chun Hsien Chu,I. Hui Lee,Tzung Lieh Yeh,Nian-Sheng Tzeng,San Yuan Huang,Yen Kuang Yang,Ru Band Lu +11 more
TL;DR: BP-II patients with comorbid ANX showed poorer neuropsychological functions than those in the BP-II-only and control groups, and both patients and controls showed equal cognitive performance.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
Journal ArticleDOI
Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data
Joan Kaufman,Boris Birmaher,David A. Brent,Uma Rao,Uma Rao,Cynthia Flynn,Cynthia Flynn,Paula Moreci,Douglas E. Williamson,Neal D. Ryan +9 more
TL;DR: Results suggest the K-SADS-PL generates reliable and valid child psychiatric diagnoses.
Journal ArticleDOI
The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Doreen S. Koretz,Kathleen R. Merikangas,A. John Rush,Ellen E. Walters,Philip S. Wang +8 more
TL;DR: Notably, major depressive disorder is a common disorder, widely distributed in the population, and usually associated with substantial symptom severity and role impairment, and while the recent increase in treatment is encouraging, inadequate treatment is a serious concern.
Journal ArticleDOI
A rating scale for mania: reliability, validity and sensitivity.
TL;DR: The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently, and also correlated with the number of days of subsequent stay in hospital.