Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication
Kathleen R. Merikangas,Hagop S. Akiskal,Jules Angst,Paul E. Greenberg,Robert M. A. Hirschfeld,Maria Petukhova,Ronald C. Kessler +6 more
TLDR
This study presents the first prevalence estimates of the BPD spectrum in a probability sample of the United States, and finds subthreshold BPD is common, clinically significant, and underdetected in treatment settings.Abstract:
The estimated lifetime prevalence of bipolar disorder (BPD) in population surveys using structured diagnostic interviews and standardized criteria averages approximately 0.8% for BP-I and 1.1% for BP-II.1-8 Despite this comparatively low prevalence, BPD is a leading cause of premature mortality due to suicide and associated medical conditions such as diabetes and cardiovascular disease.9, 10 BPD also causes widespread role impairment.11, 12 The recurrent nature of manic and depressive episodes often leads to high direct as well as high indirect health care costs.13, 14
BPD might be even more burdensome from a societal perspective due to the fact that sub-threshold bipolar spectrum disorder has seldom been taken into consideration in examining the epidemiology of BPD. Bipolar spectrum disorder includes hypomania without major depression and hypomania of lesser severity or briefer duration than specified in the DSM and ICD criteria. Although the precise definitions are as yet unclear, recent studies suggest that bipolar spectrum disorder might affect as many as 6% of the general population.15, 16 However, bipolar spectrum disorder has not been studied previously in a nationally representative survey of the US. The purpose of the current report is to present the results of such a study based on analysis of the National Comorbidity Survey Replication (NCS-R).17 We estimate prevalence and clinical features of sub-threshold BPD in comparison to BP-I and BP-II.read more
Citations
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Journal ArticleDOI
Treatment of bipolar disorder
TL;DR: Current developments in the acute and long-term treatment of bipolar disorder are reviewed and promising future routes to therapeutic innovation are identified and existing psychotherapy protocols need to be made briefer and more efficient for improved scalability and sustainability in widespread implementation.
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Prevalence of comorbid substance use, anxiety and mood disorders in epidemiological surveys, 1990-2014: a systematic review and meta-analysis
TL;DR: The strong association between SUDs, mood and anxiety disorders is confirmed worldwide as a factor that affects the profile, course, patterns, severity and outcomes of these disorders.
Journal ArticleDOI
Comorbidities and Mortality in Bipolar Disorder A Swedish National Cohort Study
Casey Crump,Kristina Sundquist,Kristina Sundquist,Marilyn A. Winkleby,Jan Sundquist,Jan Sundquist +5 more
TL;DR: Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only.
Journal ArticleDOI
The Burden of Mental Disorders
William W. Eaton,Silvia S. Martins,Gerald Nestadt,O. Joseph Bienvenu,Diana E. Clarke,Pierre K. Alexandre +5 more
TL;DR: This review systematically summarizes data on the burden associated with 11 major mental disorders of adults and expands the range of mental disorders considered in a report on the global burden of disease, updates the literature, and adds estimates of costs.
Journal ArticleDOI
Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis
Toby Wise,Joaquim Radua,Joaquim Radua,Esther Via,Narcís Cardoner,Osamu Abe,Tracey M. Adams,Francesco Amico,Yuqi Cheng,James H. Cole,C De Azevedo Marques Périco,Daniel P. Dickstein,Tom F.D. Farrow,Thomas Frodl,Thomas Frodl,Gregory R. Wagner,Ian H. Gotlib,Oliver Gruber,Byung Joo Ham,Dominic Job,Matthew J. Kempton,M J Kim,P C M P Koolschijn,Gin S Malhi,David Mataix-Cols,David Mataix-Cols,Andrew M. McIntosh,Allison C. Nugent,John T. O'Brien,John T. O'Brien,Stefania Pezzoli,Stefania Pezzoli,Mary L. Phillips,Perminder S. Sachdev,Giacomo Salvadore,Sudhakar Selvaraj,Andrew C. Stanfield,Alan J. Thomas,M.J.D. van Tol,N.J.A. van der Wee,Dick J. Veltman,Archie Young,Cynthia H.Y. Fu,Cynthia H.Y. Fu,Anthony J. Cleare,Danilo Arnone +45 more
TL;DR: The results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes, which has the potential to inform the development of diagnostic biomarkers for these conditions.
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