Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication
Kathleen R. Merikangas,Hagop S. Akiskal,Jules Angst,Paul E. Greenberg,Robert M. A. Hirschfeld,Maria Petukhova,Ronald C. Kessler +6 more
TLDR
This study presents the first prevalence estimates of the BPD spectrum in a probability sample of the United States, and finds subthreshold BPD is common, clinically significant, and underdetected in treatment settings.Abstract:
The estimated lifetime prevalence of bipolar disorder (BPD) in population surveys using structured diagnostic interviews and standardized criteria averages approximately 0.8% for BP-I and 1.1% for BP-II.1-8 Despite this comparatively low prevalence, BPD is a leading cause of premature mortality due to suicide and associated medical conditions such as diabetes and cardiovascular disease.9, 10 BPD also causes widespread role impairment.11, 12 The recurrent nature of manic and depressive episodes often leads to high direct as well as high indirect health care costs.13, 14
BPD might be even more burdensome from a societal perspective due to the fact that sub-threshold bipolar spectrum disorder has seldom been taken into consideration in examining the epidemiology of BPD. Bipolar spectrum disorder includes hypomania without major depression and hypomania of lesser severity or briefer duration than specified in the DSM and ICD criteria. Although the precise definitions are as yet unclear, recent studies suggest that bipolar spectrum disorder might affect as many as 6% of the general population.15, 16 However, bipolar spectrum disorder has not been studied previously in a nationally representative survey of the US. The purpose of the current report is to present the results of such a study based on analysis of the National Comorbidity Survey Replication (NCS-R).17 We estimate prevalence and clinical features of sub-threshold BPD in comparison to BP-I and BP-II.read more
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Journal ArticleDOI
Four-Year Longitudinal Course of Children and Adolescents With Bipolar Spectrum Disorders: The Course and Outcome of Bipolar Youth (COBY) Study
Boris Birmaher,David Axelson,Benjamin I. Goldstein,Michael Strober,Mary Kay Gill,Jeffrey Hunt,Patricia R. Houck,Wonho Ha,Satish Iyengar,Eunice Kim,Shirley Yen,Heather Hower,Christianne Esposito-Smythers,Tina R. Goldstein,Neal D. Ryan,Martin B. Keller +15 more
TL;DR: The polarity of the index episode predicted that of subsequent episodes of bipolar spectrum disorders, and participants were symptomatic during 60% of the follow-up period, particularly with subsyndromal symptoms of depression a...
Journal ArticleDOI
Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity.
Petra Zimmermann,Tanja Brückl,Agnes Nocon,Hildegard Pfister,Roselind Lieb,Hans-Ulrich Wittchen,Florian Holsboer,Jules Angst +7 more
TL;DR: It is suggested that major depressive disorder is a heterogeneous concept including a large group with subthreshold BPD, which is clinically significant and shares similarities with BPD.
Journal ArticleDOI
Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses.
Josselin Houenou,Juliane Frommberger,Soufiane Carde,Manuela Glasbrenner,Carsten Diener,Marion Leboyer,Marion Leboyer,Michèle Wessa +7 more
TL;DR: In patients with bipolar disorder, decreased activation and diminution of gray matter were identified in a cortical-cognitive brain network that has been associated with the regulation of emotions.
Journal Article
The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid substance use disorders
TL;DR: Although certain treatments show promise in the management of mood disorders comorbid with SUDs, additional well-designed studies are needed to properly assess their potential role in specific Suds comor bid with a mood disorder.
Journal ArticleDOI
Family-Focused Treatment for Adolescents With Bipolar Disorder: Results of a 2-Year Randomized Trial
David J. Miklowitz,David Axelson,Boris Birmaher,Elizabeth L. George,Dawn O. Taylor,Christopher D. Schneck,Carol Beresford,L. Miriam Dickinson,W. Edward Craighead,David A. Brent +9 more
TL;DR: Family-focused therapy is effective in combination with pharmacotherapy in stabilizing bipolar depressive symptoms among adolescents and to establish full recovery, FFT-A may need to be supplemented with systematic care interventions effective for mania symptoms.
References
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