Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication
Kathleen R. Merikangas,Hagop S. Akiskal,Jules Angst,Paul E. Greenberg,Robert M. A. Hirschfeld,Maria Petukhova,Ronald C. Kessler +6 more
TLDR
This study presents the first prevalence estimates of the BPD spectrum in a probability sample of the United States, and finds subthreshold BPD is common, clinically significant, and underdetected in treatment settings.Abstract:
The estimated lifetime prevalence of bipolar disorder (BPD) in population surveys using structured diagnostic interviews and standardized criteria averages approximately 0.8% for BP-I and 1.1% for BP-II.1-8 Despite this comparatively low prevalence, BPD is a leading cause of premature mortality due to suicide and associated medical conditions such as diabetes and cardiovascular disease.9, 10 BPD also causes widespread role impairment.11, 12 The recurrent nature of manic and depressive episodes often leads to high direct as well as high indirect health care costs.13, 14
BPD might be even more burdensome from a societal perspective due to the fact that sub-threshold bipolar spectrum disorder has seldom been taken into consideration in examining the epidemiology of BPD. Bipolar spectrum disorder includes hypomania without major depression and hypomania of lesser severity or briefer duration than specified in the DSM and ICD criteria. Although the precise definitions are as yet unclear, recent studies suggest that bipolar spectrum disorder might affect as many as 6% of the general population.15, 16 However, bipolar spectrum disorder has not been studied previously in a nationally representative survey of the US. The purpose of the current report is to present the results of such a study based on analysis of the National Comorbidity Survey Replication (NCS-R).17 We estimate prevalence and clinical features of sub-threshold BPD in comparison to BP-I and BP-II.read more
Citations
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Journal ArticleDOI
An evolutionary approach to mania studying Sardinian immigrants to Argentina
Mauro Giovanni Carta,Alessandra Perra,Michela Atzeni,Silvia D’Oca,Maria Francesca Moro,Maria Francesca Moro,Peter Konstantin Kurotschka,Daniela Moro,Federica Sancassiani,Luigi Minerba,Maria Veronica Brasesco,Gustavo Mausel,Antonio Egidio Nardi,Leonardo Tondo +13 more
TL;DR: The first study to show a higher lifetime prevalence of manic/hypomanic episodes in a general-population sample of individuals who migrated to a foreign country is shown, in agreement with the hypothesis that hyperactive/novelty-seeking features may represent an adaptive substrate in certain conditions of social change.
Journal ArticleDOI
The feasibility and acceptability of a novel anxiety in bipolar disorder intervention compared to treatment as usual: A randomized controlled trial
Steven Jones,Dawn Knowles,Elizabeth Tyler,Fiona Holland,Sarah Peters,Fiona Lobban,Brian Langshaw,Claire Hilton,Rita Long,Kay Gantt,Rebecca Owen,Chris Roberts,Lisa Riste +12 more
TL;DR: A novel psychological intervention is described to address anxiety in context of bipolar disorder (AIBD) to improve clinical outcomes including increased suicidality.
Journal ArticleDOI
Management of Bipolar II Disorder.
TL;DR: There is a need for large, well-designed RCTs to cast more definitive light on how best to manage patients with BP II disorder, and the current clinical debate over whether one should use antidepressants as monotherapy or in combination with a mood stabilizer when treating BP II depression is not yet settled.
Journal ArticleDOI
Differences between unipolar depression and bipolar II depression in women.
TL;DR: Among a sample of women, number of prior episodes, feelings of worthlessness, age of onset, and sleep patterns distinguished between UD and BP II depressive episodes.
References
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Nonparametric Estimation from Incomplete Observations
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Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
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Journal ArticleDOI
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