Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication
Kathleen R. Merikangas,Hagop S. Akiskal,Jules Angst,Paul E. Greenberg,Robert M. A. Hirschfeld,Maria Petukhova,Ronald C. Kessler +6 more
TLDR
This study presents the first prevalence estimates of the BPD spectrum in a probability sample of the United States, and finds subthreshold BPD is common, clinically significant, and underdetected in treatment settings.Abstract:
The estimated lifetime prevalence of bipolar disorder (BPD) in population surveys using structured diagnostic interviews and standardized criteria averages approximately 0.8% for BP-I and 1.1% for BP-II.1-8 Despite this comparatively low prevalence, BPD is a leading cause of premature mortality due to suicide and associated medical conditions such as diabetes and cardiovascular disease.9, 10 BPD also causes widespread role impairment.11, 12 The recurrent nature of manic and depressive episodes often leads to high direct as well as high indirect health care costs.13, 14
BPD might be even more burdensome from a societal perspective due to the fact that sub-threshold bipolar spectrum disorder has seldom been taken into consideration in examining the epidemiology of BPD. Bipolar spectrum disorder includes hypomania without major depression and hypomania of lesser severity or briefer duration than specified in the DSM and ICD criteria. Although the precise definitions are as yet unclear, recent studies suggest that bipolar spectrum disorder might affect as many as 6% of the general population.15, 16 However, bipolar spectrum disorder has not been studied previously in a nationally representative survey of the US. The purpose of the current report is to present the results of such a study based on analysis of the National Comorbidity Survey Replication (NCS-R).17 We estimate prevalence and clinical features of sub-threshold BPD in comparison to BP-I and BP-II.read more
Citations
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Journal ArticleDOI
Systematic Review of Symptom Assessment Measures for Use in Measurement-Based Care of Bipolar Disorders.
Joseph M. Cerimele,Simon B. Goldberg,Christopher J. Miller,Stephen W Gabrielson,John C Fortney +4 more
TL;DR: This study synthesizes the literature on patient-reported and clinician-observed measures of symptoms of bipolar disorder and the potential use of these measures in MBC, finding suitable choices are available for MBC of bipolar disorders.
Journal ArticleDOI
Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder.
Edyta Koman-Wierdak,Joanna Rog,Agnieszka Brzozowska,Mario Damiano Toro,Mario Damiano Toro,Vincenza Bonfiglio,Katarzyna Załuska-Ogryzek,Hanna Karakuła-Juchnowicz,Robert Rejdak,Katarzyna Nowomiejska +9 more
TL;DR: In this article, the peripapillary capillary (RPC) density and RNFL thickness were measured in both superficial and deep layers of the macula in patients with schizophrenia and bipolar disorder.
Journal ArticleDOI
Mind the Gap: Developing an Integrated Behavioral Health Home to Address Health Disparities in Serious Mental Illness.
Miriam C. Tepper,Alexander M. Cohen,Ana M. Progovac,Andrea Ault-Brutus,H. Stephen Leff,Brian O. Mullin,Carrie Cunningham,Benjamin Lê Cook +7 more
TL;DR: Participation in a pilot ambulatory BHH program among patients with psychotic and bipolar disorders was associated with significant reductions in ED visits and psychiatric hospitalizations and increased HbA1c monitoring.
Journal ArticleDOI
Effects of antipsychotic drugs on cardiovascular variability in participants with bipolar disorder
Jonathan R. Linder,Simrit K. Sodhi,William G. Haynes,William G. Haynes,Jess G. Fiedorowicz,Jess G. Fiedorowicz +5 more
TL;DR: The hypothesis that current and cumulative antipsychotic drug exposure is associated with increased cardiovascular risk as indicated by lower heart rate variability (HRV) and increased blood pressure variability (BPV) is tested.
Journal ArticleDOI
Inflammatory Markers in the Staging of Bipolar Disorder: A Systematic Review of the Literature.
Oscar Mauricio Castano-Ramirez,Juan Carlos Sepúlveda-Arias,Kelly Duica,Ana M. Díaz Zuluaga,Cristian Vargas,Carlos López-Jaramillo +5 more
TL;DR: This study suggests that TNF and ILs could play a role in neuroprogression of Bipolar Disorder, however, longitudinal studies are needed to clarify the relationship between factors associated with neuro Progression.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
Journal ArticleDOI
Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data
Joan Kaufman,Boris Birmaher,David A. Brent,Uma Rao,Uma Rao,Cynthia Flynn,Cynthia Flynn,Paula Moreci,Douglas E. Williamson,Neal D. Ryan +9 more
TL;DR: Results suggest the K-SADS-PL generates reliable and valid child psychiatric diagnoses.
Journal ArticleDOI
The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Doreen S. Koretz,Kathleen R. Merikangas,A. John Rush,Ellen E. Walters,Philip S. Wang +8 more
TL;DR: Notably, major depressive disorder is a common disorder, widely distributed in the population, and usually associated with substantial symptom severity and role impairment, and while the recent increase in treatment is encouraging, inadequate treatment is a serious concern.
Journal ArticleDOI
A rating scale for mania: reliability, validity and sensitivity.
TL;DR: The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently, and also correlated with the number of days of subsequent stay in hospital.