Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication
Kathleen R. Merikangas,Hagop S. Akiskal,Jules Angst,Paul E. Greenberg,Robert M. A. Hirschfeld,Maria Petukhova,Ronald C. Kessler +6 more
TLDR
This study presents the first prevalence estimates of the BPD spectrum in a probability sample of the United States, and finds subthreshold BPD is common, clinically significant, and underdetected in treatment settings.Abstract:
The estimated lifetime prevalence of bipolar disorder (BPD) in population surveys using structured diagnostic interviews and standardized criteria averages approximately 0.8% for BP-I and 1.1% for BP-II.1-8 Despite this comparatively low prevalence, BPD is a leading cause of premature mortality due to suicide and associated medical conditions such as diabetes and cardiovascular disease.9, 10 BPD also causes widespread role impairment.11, 12 The recurrent nature of manic and depressive episodes often leads to high direct as well as high indirect health care costs.13, 14
BPD might be even more burdensome from a societal perspective due to the fact that sub-threshold bipolar spectrum disorder has seldom been taken into consideration in examining the epidemiology of BPD. Bipolar spectrum disorder includes hypomania without major depression and hypomania of lesser severity or briefer duration than specified in the DSM and ICD criteria. Although the precise definitions are as yet unclear, recent studies suggest that bipolar spectrum disorder might affect as many as 6% of the general population.15, 16 However, bipolar spectrum disorder has not been studied previously in a nationally representative survey of the US. The purpose of the current report is to present the results of such a study based on analysis of the National Comorbidity Survey Replication (NCS-R).17 We estimate prevalence and clinical features of sub-threshold BPD in comparison to BP-I and BP-II.read more
Citations
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Family Care giving in Bipolar disorder: Experiences of Stigma.
TL;DR: For a person with bipolar disorder, this illness is associated with the following problems: worse recovery, difficulty accessing health services, receiving poor treatment and support, and difficulty gaining community acceptance.
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Efficacy of a Maternal Depression Prevention Strategy in Head Start: A Randomized Clinical Trial.
Michael Silverstein,Yaminette Diaz-Linhart,Howard Cabral,William R. Beardslee,Mark T. Hegel,Winta Haile,Jenna Sander,Gregory Patts,Emily Feinberg +8 more
TL;DR: The PSE intervention is efficacious in preventing depressive symptom episodes and performs optimally among those with initial low-level symptoms, and additional effectiveness studies in Head Start are necessary to develop meaningful public health programs.
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The Importance of Anxiety States in Bipolar Disorder
TL;DR: Treatment studies of bipolar patients with comorbid anxiety have begun to provide preliminary evidence for the role of specific pharmacological and psychotherapeutic treatments, but these need to be confirmed in more definitive trials.
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Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder
Richard C. McEachin,Nancy L. Saccone,Scott F. Saccone,Yelena D Kleyman-Smith,Tiara Kar,Rajesh K Kare,Alex Ade,Maureen A. Sartor,James D. Cavalcoli,Melvin G. McInnis +9 more
TL;DR: A 69 gene network that influences neurotransmitter signaling and shows significant over-representation of genes associated with BD and TUD, as well as genes differentially expressed with exposure to tobacco smoke, is identified.
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Performance of the Bipolar Spectrum Diagnostic Scale in psychiatric outpatients
TL;DR: With its high negative predictive value, the BSDS was excellent at ruling out a diagnosis of bipolar disorder; however, the low positive predictive value indicates that it is not good at ruling in the diagnosis.
References
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