Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria
TLDR
A light‐activated rhenium complex with activity against drug‐resistant S. aureus and E. coli suggests two distinct modes of action.Abstract:
New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal-complexes offer access to potential alternative modes of action and have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug resistant bacteria. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.read more
Citations
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Metal Complexes, an Untapped Source of Antibiotic Potential?
TL;DR: The encouraging work that has been done on antimicrobial metal complexes, mainly over the last decade, is highlighted and possible modes of action are discussed and issues that remain to be addressed are emphasized.
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Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12
Sara Nasiri Sovari,Fabio Zobi +1 more
TL;DR: This review describes recent studies on the antimicrobial activity of transition metal complexes of groups 6–12 and focuses on the effectiveness of the metal complexes in relation to the rich structural chemical variations of the same.
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Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA).
Sara Nasiri Sovari,Sandra Vojnovic,Sanja Skaro Bogojevic,Aurélien Crochet,Aleksandar Pavic,Jasmina Nikodinovic-Runic,Fabio Zobi +6 more
TL;DR: In the zebrafish-MRSA infection model, the complexes with anti-staphylococcal/MRSA activity were non-toxic to the organism even at much higher doses of the corresponding MICs, and markedly reduced bacterial burden.
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Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity.
TL;DR: In this article, a review summarizes recent progress in the field of organometallic-derived antibacterial drugs and metal-based materials having antibacterial activity, including β-lactams, ciprofloxacin, isoniazid, trimethoprim, sulfadoxine, sulfamethoxazole, and ethambutol.
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Anticancer and Antibiotic Rhenium Tri- and Dicarbonyl Complexes: Current Research and Future Perspectives
Kevin S. Schindler,Fabio Zobi +1 more
TL;DR: In this paper , the authors discuss the anticancer and antibiotic properties of rhenium tri-and dicarbonyl complexes described in the last seven years, mainly in terms of their structural variations and in vitro efficacy.
References
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