Links between gut microbiome composition and fatty liver disease in a large population sample
Matti O. Ruuskanen,Matti O. Ruuskanen,Fredrik Åberg,Fredrik Åberg,Ville Männistö,Ville Männistö,Aki S. Havulinna,Guillaume Méric,Guillaume Méric,Yang Liu,Yang Liu,Rohit Loomba,Yoshiki Vázquez-Baeza,Yoshiki Vázquez-Baeza,Anupriya Tripathi,Anupriya Tripathi,Liisa Valsta,Michael Inouye,Michael Inouye,Pekka Jousilahti,Veikko Salomaa,Mohit Jain,Mohit Jain,Rob Knight,Leo Lahti,Teemu J. Niiranen,Teemu J. Niiranen,Teemu J. Niiranen +27 more
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TLDR
Through modeling the fatty liver index, the results provide with high resolution associations between gut microbiota composition and fatty liver in a large representative population cohort, and lend further support to the role of endogenous ethanol producers in the development of fatty liver.Abstract:
Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 years, but this association remains mostly unstudied in the general population because of underdiagnosis and small sample sizes. To address this knowledge gap, we studied the link between the Fatty Liver Index (FLI), a well-established proxy for fatty liver disease, and gut microbiome composition in a representative, ethnically homogeneous population sample of 6,269 Finnish participants. We based our models on biometric covariates and gut microbiome compositions from shallow metagenome sequencing. Our classification models could discriminate between individuals with a high FLI (≥ 60, indicates likely liver steatosis) and low FLI (read more
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Applications of Machine Learning in Human Microbiome Studies: A Review on Feature Selection, Biomarker Identification, Disease Prediction and Treatment.
Laura Judith Marcos-Zambrano,Kanita Karaduzovic-Hadziabdic,Tatjana Loncar Turukalo,Piotr Przymus,Vladimir Trajkovik,Oliver Aasmets,Magali Berland,Aleksandra Gruca,Jasminka Hasic,Karel Hron,Thomas Klammsteiner,Mikhail Kolev,Leo Lahti,Marta B. Lopes,Victor Moreno,Irina Naskinova,Elin Org,Inês Paciência,Georgios Papoutsoglou,Rajesh Shigdel,Blaz Stres,Baiba Vilne,Malik Yousef,Eftim Zdravevski,Ioannis Tsamardinos,Enrique Carrillo de Santa Pau,Marcus J. Claesson,Isabel Moreno-Indias,Isabel Moreno-Indias,Jaak Truu +29 more
TL;DR: In this paper, a review of the state-of-the-art ML methods and respective software applied in human microbiome studies, performed as part of the COST Action ML4Microbiome activities, is presented.
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Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort
Youwen Qin,Aki S. Havulinna,Liu Yang,Pekka Jousilahti,Scott C. Ritchie,Alex Tokolyi,Jon G. Sanders,Liisa Valsta,Marta Brozynska,Qiyun Zhu,Anupriya Tripathi,Yoshiki Vázquez-Baeza,Rohit Loomba,Susan Cheng,Mohit Jain,Teemu J. Niiranen,Leo Lahti,Rob Knight,Veikko Salomaa,Michael Inouye,Guillaume Méric +20 more
TL;DR: A combination of genetics and dietary habits was shown to strongly shape the abundances of certain key bacterial members of the gut microbiota, and explain their genetic association, and this work identifies putative causal relationships between gut microbes and complex diseases using MR.
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Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease.
TL;DR: In this paper , the effects of mild-moderate alcohol consumption on the risk of metabolic syndrome and fatty liver disease have been investigated, and it has been shown that alcohol and metabolic factors are independently and jointly associated with liver-related outcomes.
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Ali Amoushahi,Elham Moazam,Amin Reza Tabatabaei,G. Ghasimi,Ian Grant-Whyte,P.A. Salvatori,Ahmed Ragab Ezz +6 more
TL;DR: In this article , the efficacy and safety of nebulized ethanol (EtOH) in treating Coronavirus disease 2019 (COVID-19) is evaluated in a randomized clinical trial with 99 patients admitted to a hospital receiving remdesivir-dexamethasone.
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