Journal ArticleDOI
Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches
Gonzalo Sapisochin,Jordi Bruix +1 more
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TLDR
A comprehensive overview of the outcomes after liver transplantation for HCC, focusing on tumour recurrence in terms of surveillance, prevention and treatment is provided.Abstract:
Liver transplantation for hepatocellular carcinoma (HCC) is the best treatment option for patients with early-stage tumours and accounts for ∼20-40% of all liver transplantations performed at most centres worldwide. The Milan criteria are the most common criteria to select patients with HCC for transplantation but they can be seen as too restrictive. Several proposals have been made for a moderate expansion of the criteria, which result in good outcomes but with an increase in the risk of tumour recurrence. In this Review, we provide a comprehensive overview of the outcomes after liver transplantation for HCC, focusing on tumour recurrence in terms of surveillance, prevention and treatment. Additionally, novel surgical techniques have been developed to increase the available pool of organs for liver transplantation (such as living donor liver transplantation, donation after circulatory death and split livers), but the effect of these techniques on patients with HCC is still under debate. Thus, we will describe these techniques and expose the benefits and disadvantages of each surgical approach. Finally, we will comment on the limitations of the current priority policies for liver transplantation and the need to further refine them to better serve the population.read more
Citations
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Proceedings ArticleDOI
Multimodal Sonographic Assessment of Hepatocellular Carcinoma Response to Antivascular Therapy
Julia C D'Souza,Laith R. Sultan,Stephen J. Hunt,Mrigendra B. Karmacharya,Angela K Brice,Andrew Ak Wood,Chandra M. Sehgal +6 more
TL;DR: Different modes of contrast-enhanced ultrasound imaging along with histology confirmed disruption of tumor perfusion induced by AVUS therapy, which validation in a translational model sets the stage for future evaluation of AVUS to treat HCC in human subject.
Journal ArticleDOI
Microwave ablation versus radiofrequency ablation as bridge therapy in potentially transplantable patients with single HCC ≤ 3 cm: A propensity score-matched study.
Xueqi Wang,Hongli Yu,Fenglin Zhao,Yayun Xu,Chunzhao Wang,Kaiwen Liu,Bo Liu,Hang Zheng,Yingjie Wei,Xinyu Wang,Qiang Zhu,Mingzheng Huang,Yuemin Feng +12 more
TL;DR: In this paper , the authors compared the recurrence beyond the Milan criteria (RBM) rates in potentially transplantable patients with HCC receiving MWA or radiofrequency ablation (RFA) as bridge therapy.
Journal ArticleDOI
Development of a deep pathomics score for predicting hepatocellular carcinoma recurrence after liver transplantation.
Wei-Feng Qu,Mengxin Tian,Hongxia Lu,Yu-Fu Zhou,Wei-Ren Liu,Zheng Tang,Zhao Yao,Rui Huang,Gui-Qi Zhu,Xi-Fei Jiang,Chen-Yang Tao,Yuan Fang,Junqin Gao,Xiao Ling Wu,Jia-Feng Chen,Rui Yang,Tianyao Chu,Jian Zhou,Jia Fan,Ying-Hong Shi +19 more
TL;DR: Wang et al. as discussed by the authors developed a deep pathomics score (DPS) for predicting tumor recurrence after liver transplantation using deep learning, and two datasets of 380 HCC patients who underwent LT were enrolled.
Patent
Method for predicting the survival time of a patient suffering from hepatocellular carcinoma
TL;DR: In this article, a method for predicting the survival time of a patient suffering from HCC comprising determining the expression level of the genes elected in the group consisting in AGXT, FETUB, GLS2, GNMT, SLC10A1 and SLC22A7 was proposed.
Journal ArticleDOI
Progression of hepatocellular carcinoma after radiofrequency ablation: Current status of research
Shilun Wu,Zhuxin Li,Changyu Yao,Shuying Dong,Jun Gao,Shan Ke,Ruhang Zhu,Sen Huang,Shaohong Wang,Li Li Xu,Jian Kong,Wenbing Sun +11 more
TL;DR: In this paper , a review summarizes the relevant literature and the possible mechanisms involved in progression of HCC after RFA, which is often attributed to the vascular thermal deposition effect, the wide infiltration zone of peripheral venules and the distance between satellite foci and the main focus of the cancer.
References
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Journal ArticleDOI
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
TL;DR: The GLOBOCAN series of the International Agency for Research on Cancer (IARC) as mentioned in this paper provides estimates of the worldwide incidence and mortality from 27 major cancers and for all cancers combined for 2012.
Journal ArticleDOI
Sorafenib in Advanced Hepatocellular Carcinoma
Josep M. Llovet,Sergio Ricci,Vincenzo Mazzaferro,Philip Hilgard,Edward Gane,Jean-Frédéric Blanc,André Cosme de Oliveira,Armando Santoro,Jean-Luc Raoul,Alejandro Forner,Myron Schwartz,Camillo Porta,Stefan Zeuzem,Luigi Bolondi,Tim F. Greten,Peter R. Galle,Jean Francois Seitz,Ivan Borbath,Dieter Häussinger,Tom Giannaris,Minghua Shan,M. Moscovici,D. Voliotis,Jordi Bruix +23 more
TL;DR: In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
Journal ArticleDOI
EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma
Peter R. Galle,Alejandro Forner,Josep M. Llovet,Vincenzo Mazzaferro,Fabio Piscaglia,Jean-Luc Raoul,Peter Schirmacher,Valérie Vilgrain +7 more
TL;DR: The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
Journal ArticleDOI
Management of hepatocellular carcinoma: An update
Jordi Bruix,Morris Sherman +1 more
TL;DR: The American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) were updated in 2010 as discussed by the authors.
AASLD PRACTICE GUIDELINE Management of Hepatocellular Carcinoma: An Update
Jordi Bruix,Morris Sherman +1 more
TL;DR: Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) in 2005, new information has emerged that requires that the guidelines be updated.
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