Journal ArticleDOI
Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches
Gonzalo Sapisochin,Jordi Bruix +1 more
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TLDR
A comprehensive overview of the outcomes after liver transplantation for HCC, focusing on tumour recurrence in terms of surveillance, prevention and treatment is provided.Abstract:
Liver transplantation for hepatocellular carcinoma (HCC) is the best treatment option for patients with early-stage tumours and accounts for ∼20-40% of all liver transplantations performed at most centres worldwide. The Milan criteria are the most common criteria to select patients with HCC for transplantation but they can be seen as too restrictive. Several proposals have been made for a moderate expansion of the criteria, which result in good outcomes but with an increase in the risk of tumour recurrence. In this Review, we provide a comprehensive overview of the outcomes after liver transplantation for HCC, focusing on tumour recurrence in terms of surveillance, prevention and treatment. Additionally, novel surgical techniques have been developed to increase the available pool of organs for liver transplantation (such as living donor liver transplantation, donation after circulatory death and split livers), but the effect of these techniques on patients with HCC is still under debate. Thus, we will describe these techniques and expose the benefits and disadvantages of each surgical approach. Finally, we will comment on the limitations of the current priority policies for liver transplantation and the need to further refine them to better serve the population.read more
Citations
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Journal ArticleDOI
Liver transplantation for colorectal liver metastasis
TL;DR: Evidence suggests a potential survival benefit of liver transplantation for a subset of patients with unresectable liver-limited CRLM, and the role and feasibility of this treatment strategy in oncotransplantation.
Journal ArticleDOI
Serum Factor V Is a Continuous Biomarker of Graft Dysfunction and a Predictor of Graft Loss After Liver Transplantation.
Andre Gorgen,Carolina Prediger,João E Prediger,Marcio F. Chedid,Ariane Nádia Backes,Alexandre de Araujo,Tomaz J. M. Grezzana-Filho,Ian Leipnitz,Aljamir Duarte Chedid,Mário Reis Álvares-da-Silva,Gonzalo Sapisochin,Cleber Rosito Pinto Kruel +11 more
TL;DR: Factor V is an early marker for EAD and is a continuous predictor of short-term graft loss after liver transplantation (LT), whereas EAD was not significant when adjusted for factor V.
Journal ArticleDOI
Management of Hepatocellular Carcinoma Recurrence after Liver Transplantation
Filippo Pelizzaro,Martina Gambato,Enrico Gringeri,Alessandro Vitale,Umberto Cillo,Fabio Farinati,Patrizia Burra,Francesco Paolo Russo +7 more
TL;DR: In this article, the available evidence on the management of hepatocellular carcinoma recurrence after liver transplantation is comprehensively reviewed, considering pre-and post-transplant risk stratification, posttransplant surveillance, preventive strategies and treatment options.
Journal ArticleDOI
6-Phosphogluconolactonase Promotes Hepatocellular Carcinogenesis by Activating Pentose Phosphate Pathway.
Changzheng Li,Changzheng Li,Jie Chen,Yishan Li,Binghuo Wu,Zhitao Ye,Xiaobin Tian,Yan Wei,Zechen Hao,Yuan Pan,Hongli Zhou,Keyue Yang,Zhiqiang Fu,Jingbo Xu,Yanan Lu +14 more
TL;DR: Wang et al. as mentioned in this paper found that 6-phosphogluconolactonase (PGLS), a cytosolic enzyme in the oxidative phase of the pentose phosphate pathway (PPP), expressing cells are associated with undifferentiated HCC subtypes.
Journal ArticleDOI
Sphingosine-1-phosphate transporter spinster homologue 2 is essential for iron-regulated metastasis of hepatocellular carcinoma
Min Li,Min Li,Yuxiao Tang,Dongyao Wang,Xiao-feng Zhai,Hui Shen,Chen Zhong,Man Yao,Aiguo Jin,Zheng-Jun Zhou,Shao-Lai Zhou,Jia Fan,Changquan Ling,Chen Ling +13 more
TL;DR: In this paper, the role of iron in hepatocellular carcinoma (HCC) development was investigated in both cell cultures and clinical samples in vitro, using IR mouse models were generated using iron-free diet and transferrin receptor protein knock out, followed by administration of HCC tumors through either orthotopic or ectopic route.
References
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Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
TL;DR: The GLOBOCAN series of the International Agency for Research on Cancer (IARC) as mentioned in this paper provides estimates of the worldwide incidence and mortality from 27 major cancers and for all cancers combined for 2012.
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Sorafenib in Advanced Hepatocellular Carcinoma
Josep M. Llovet,Sergio Ricci,Vincenzo Mazzaferro,Philip Hilgard,Edward Gane,Jean-Frédéric Blanc,André Cosme de Oliveira,Armando Santoro,Jean-Luc Raoul,Alejandro Forner,Myron Schwartz,Camillo Porta,Stefan Zeuzem,Luigi Bolondi,Tim F. Greten,Peter R. Galle,Jean Francois Seitz,Ivan Borbath,Dieter Häussinger,Tom Giannaris,Minghua Shan,M. Moscovici,D. Voliotis,Jordi Bruix +23 more
TL;DR: In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
Journal ArticleDOI
EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma
Peter R. Galle,Alejandro Forner,Josep M. Llovet,Vincenzo Mazzaferro,Fabio Piscaglia,Jean-Luc Raoul,Peter Schirmacher,Valérie Vilgrain +7 more
TL;DR: The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
Journal ArticleDOI
Management of hepatocellular carcinoma: An update
Jordi Bruix,Morris Sherman +1 more
TL;DR: The American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) were updated in 2010 as discussed by the authors.
AASLD PRACTICE GUIDELINE Management of Hepatocellular Carcinoma: An Update
Jordi Bruix,Morris Sherman +1 more
TL;DR: Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) in 2005, new information has emerged that requires that the guidelines be updated.
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