Journal ArticleDOI
Loading hydrophilic drug in solid lipid media as nanoparticles: Statistical modeling of entrapment efficiency and particle size
Maryam Ghadiri,Shohreh Fatemi,Alireza Vatanara,Delaram Doroud,Abdolhossein Rouholamini Najafabadi,Majid Darabi,Amir Abbas Rahimi +6 more
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TLDR
The drug release profile of the optimal formulated material was examined in aqueous media and 64% of the Paromomycin loaded in SLNs was gradually released during 24h, which reveals efficient prolonged release of the drug.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2012-03-15. It has received 116 citations till now. The article focuses on the topics: Cetyl palmitate & Solid lipid nanoparticle.read more
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Optimisation and stability assessment of solid lipid nanoparticles using particle size and zeta potential
TL;DR: In this article, the physicochemical properties such as particle size, polydispersity index (PI) and zeta potential are evaluated for solid lipid nanoparticles (SLNs) in order to understand the influence of variation in SLN composition (lipid and emulsifier concentration).
Journal ArticleDOI
Advances in brain drug targeting and delivery: limitations and challenges of solid lipid nanoparticles.
TL;DR: The present review discusses the limitations to CNS drug delivery, and the various approaches to bypass the blood brain barrier (BBB), focusing on the potential use of solid lipid nanoparticles (SLN) for drug targeting to brain.
Journal ArticleDOI
Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: Antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies
Patrícia Severino,Marco Vinícius Chaud,Andréa Arruda Martins Shimojo,Danilo Antonini,Marcelo Lancelloti,Maria Helena Andrade Santana,Eliana B. Souto +6 more
TL;DR: In this paper, the authors describe an innovative method to load polymyxin B sulphate (PLX) into solid lipid nanoparticles (SLN) to achieve the sustained release of the drug.
Journal ArticleDOI
Irinotecan-encapsulated double-reverse thermosensitive nanocarrier system for rectal administration
Fakhar ud Din,Ju Yeon Choi,Dong Wuk Kim,Omer Mustapha,Dong Shik Kim,Raj Kumar Thapa,Sae-Kwang Ku,Yu Seok Youn,Kyung Taek Oh,Chul Soon Yong,Jong Oh Kim,Han-Gon Choi +11 more
TL;DR: The DRTN gave sustained release and nearly constant plasma concentrations of irinotecan at 1–3 h in rats, resulting in improved anticancer activity, and would be strongly recommended as a rectal pharmaceutical product alternative to commercial intravenous injection in the treatment of rectum and colon cancer.
Journal ArticleDOI
Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery
TL;DR: SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skin and significantly increased drug penetration through rat skin compared to the gel.
References
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Journal ArticleDOI
Simultaneous Optimization of Several Response Variables
TL;DR: In this article, the authors present a set of conditions that will result in a product with a desirable combination of properties, which is a problem facing the product development community in general.
Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Journal ArticleDOI
Advances in leishmaniasis.
TL;DR: Governed by parasite and host factors and immunoinflammatory responses, the clinical spectrum of leishmaniasis encompasses subclinical (inapparent), localised (skin lesions), and disseminated infection (cutaneous, mucosal, or visceral).
Book
Pharmaceutical Experimental Design
TL;DR: This chapter discusses screening, factor influence studies, statistical and Mathematical tools, and choice of computer software for Screening.
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Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more