Loss of Synaptic Depression in Mammalian Anterior Cingulate Cortex after Amputation
TLDR
It is reported that NMDA receptor-independent LTD is the major form of long-term plasticity in the anterior cingulate cortex (ACC), and it is suggested that synaptic LTD in the ACC may contribute to enhanced neuronal responses to subsequent somatosensory stimuli after amputation.Abstract:
Two forms of activity-dependent long-term depression (LTD) in the CNS, as defined by their sensitivity to the blockade of NMDA receptors, are thought to be important in learning, memory, and development. Here, we report that NMDA receptor-independent LTD is the major form of long-term plasticity in the anterior cingulate cortex (ACC). Both L-type voltage-gated calcium channels and metabotropic glutamate receptors are required for inducing LTD. Amputation of a third hindpaw digit in an adult rat induced rapid expression of immediate early genes in the ACC bilaterally and caused a loss of LTD that persisted for at least 2 weeks. Our results suggest that synaptic LTD in the ACC may contribute to enhanced neuronal responses to subsequent somatosensory stimuli after amputation.read more
Citations
More filters
Journal ArticleDOI
LDL-receptor-related proteins in Wnt signal transduction
Keiko Tamai,Mikhall Semenov,Yolchi Kato,Rebecca Spokony,Chunming Liu,Yu Katsuyama,Fred Hess,Jean Pierre Saint-Jeannet,Xi He +8 more
TL;DR: In Xenopus embryos, LRP6 activated Wnt–Fz signalling, and induced Wnt responsive genes, dorsal axis duplication and neural crest formation, indicating that LRP 6 may be a component of the Wnt receptor complex.
Journal ArticleDOI
Chronic pain may change the structure of the brain
TL;DR: The author suggests that the gray matter change observed in chronic pain patients are the consequence of frequent nociceptive input and should thus be reversible when pain is adequately treated.
Journal ArticleDOI
Phantom-limb pain: characteristics, causes, and treatment
TL;DR: A comprehensive model of phantom-limb pain is presented that assigns major roles to pain occurring before the amputation and to central as well as peripheral changes related to it.
Journal ArticleDOI
Roles of NMDA NR2B Subtype Receptor in Prefrontal Long-Term Potentiation and Contextual Fear Memory
Ming Gao Zhao,Hiroki Toyoda,Yong-Seok Lee,Yong-Seok Lee,Long Jun Wu,Long Jun Wu,Shanelle W. Ko,Xue Han Zhang,Yongheng Jia,Fanny W.F. Shum,Hui Xu,Bao Ming Li,Bong-Kiun Kaang,Bong-Kiun Kaang,Min Zhuo,Min Zhuo +15 more
TL;DR: It is reported that the activation of the NR2B and NR2A subunits of the NMDA receptor is critical for the induction of cingulate LTP, regardless of the induction protocol.
Journal ArticleDOI
Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain
TL;DR: Increasing evidence from rodent studies that ACC activation contributes to chronic pain states is discussed and several forms of synaptic plasticity that may underlie this effect are described.
References
More filters
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Contributions of anterior cingulate cortex to behaviour.
TL;DR: The cingulate epilepsy syndrome provides important support of experimental animal and human functional imaging studies for the role of anterior cingulates cortex in movement, affect and social behaviours.
Journal ArticleDOI
Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun
James I. Morgan,Tom Curran +1 more
Journal ArticleDOI
Pain affect encoded in human anterior cingulate but not somatosensory cortex.
TL;DR: These findings provide direct experimental evidence in humans linking frontal-lobe limbic activity with pain affect, as originally suggested by early clinical lesion studies.
Related Papers (5)
Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKMζ in the Anterior Cingulate Cortex
Xiang-Yao Li,Xiang-Yao Li,Hyoung-Gon Ko,Tao Chen,Tao Chen,Giannina Descalzi,Kohei Koga,Hansen Wang,Susan S. Kim,Yuze Shang,Chuljung Kwak,Soowon Park,Jaehoon Shim,Jaehoon Shim,Kyungmin Lee,Kyungmin Lee,Graham L. Collingridge,Graham L. Collingridge,Bong-Kiun Kaang,Bong-Kiun Kaang,Min Zhuo,Min Zhuo +21 more