Journal ArticleDOI
Macromolecular crowding: obvious but underappreciated.
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TLDR
Positive results of crowding include enhancing the collapse of polypeptide chains into functional proteins, the assembly of oligomeric structures and the efficiency of action of some molecular chaperones and metabolic pathways.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2001-10-01. It has received 2104 citations till now. The article focuses on the topics: Macromolecular crowding & Chaperone (protein).read more
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The surface science of nanocrystals.
Michael A. Boles,Daishun Ling,Daishun Ling,Taeghwan Hyeon,Dmitri V. Talapin,Dmitri V. Talapin +5 more
TL;DR: The role of surface ligands in tuning and rationally designing properties of functional nanomaterials and their importance for biomedical and optoelectronic applications is focused on and an assessment of application-targeted surface engineering is concluded.
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One step at a time: endoplasmic reticulum-associated degradation
TL;DR: The current understanding of each step during ERAD, with emphasis on the factors that catalyse distinct activities is summarized, to highlight the importance of this pathway.
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Gene Regulation at the Single-Cell Level
TL;DR: It is found that protein production rates fluctuate over a time scale of about one cell cycle, while intrinsic noise decays rapidly, which can form a basis for quantitative modeling of natural gene circuits and for design of synthetic ones.
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Pathways of chaperone-mediated protein folding in the cytosol
TL;DR: In the cytosol of prokaryotic and eukaryotic cells, molecular chaperones of different structural classes form a network of pathways that can handle substrate polypeptides from the point of initial synthesis on ribosomes to the final stages of folding.
Journal ArticleDOI
Genome-scale models of microbial cells: evaluating the consequences of constraints
TL;DR: This work has shown that a constraint-based reconstruction and analysis approach provides a biochemically and genetically consistent framework for the generation of hypotheses and the testing of functions of microbial cells.
References
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Journal ArticleDOI
Principles that Govern the Folding of Protein Chains
TL;DR: Anfinsen as discussed by the authors provided a sketch of the rich history of research that provided the foundation for his work on protein folding and the Thermodynamic Hypothesis, and outlined potential avenues of current and future scientific exploration.
Journal ArticleDOI
The Hsp70 and Hsp60 chaperone machines.
Bernd Bukau,Arthur L. Horwich +1 more
TL;DR: This work dedicates this work to Guenter Brueckner, always an inspiration, and to Wayne Fenton for critical reading and Zhaohui Xu for figure preparation.
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Proteomics to study genes and genomes
TL;DR: Proteomics can be divided into three main areas: protein micro-characterization for large-scale identification of proteins and their post-translational modifications; ‘differential display’ proteomics for comparison of protein levels with potential application in a wide range of diseases; and studies of protein–protein interactions using techniques such as mass spectrometry or the yeast two-hybrid system.
Journal ArticleDOI
Physical Principles in the Construction of Regular Viruses
Donald L. D. Caspar,A. Klug +1 more
TL;DR: The authors' designs obey strict icosahedral symmetry, with the asymmetric unit in each case containing a heterodimer that comprises one subunit from each of the two components.
Journal ArticleDOI
Functional Significance of Cell Volume Regulatory Mechanisms
Florian Lang,Gillian L. Busch,Markus Ritter,Harald Völkl,Siegfried Waldegger,Erich Gulbins,Dieter Häussinger +6 more
TL;DR: Cell volume may be considered a second message in the transmission of hormonal signals, and alterations of cell volume and volume regulatory mechanisms participate in a wide variety of cellular functions including epithelial transport, metabolism, excitation, hormone release, migration, cell proliferation, and cell death.
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