Major Histocompatibility Complex Class I‐Related Chain A Alleles and Histology of Nonalcoholic Fatty Liver Disease
Azza Karrar,Bijal Rajput,Siddharth Hariharan,Dinan Abdelatif,Mohamad Houry,Ali Moosvi,Irfan Ali,Daisong Tan,Sohailla Noor,Donna Esmaeili,Sean Felix,Lakshmi Alaparthi,Munkhzul Otgonsuren,Brian Lam,Zachary Goodman,Zobair M. Younossi +15 more
- Vol. 5, Iss: 1, pp 63-73
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TLDR
MICA alleles may be associated with NASH and its histologic features of inflammation and fibrosis and additional research is required to investigate the potential role of MICA in increased risk or protection against NAFLD.Citations
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Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases
Rocío Gallego-Durán,Rocío Montero-Vallejo,Douglas Maya-Miles,Ana Lucena,Franz Martín,Javier Ampuero,Manuel Romero-Gómez +6 more
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The immunological role of ADAMs in the field of gastroenterological chronic inflammatory diseases and cancers: a review
TL;DR: In this article , a review summarizes the current understanding of the role of ADAMs in gastroenterological diseases with regard to the immune system, including MICB, ICAM-1, TNF-α, IL-6 receptor (IL-6R), and Notch.
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The Important Roles of Natural Killer Cells in Liver Fibrosis
TL;DR: In this paper , the authors summarized the cellular and molecular factors that affect the interaction of NK cells with HSCs, as well as the treatments that regulate NK cell function against liver fibrosis.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Senescence of activated stellate cells limits liver fibrosis
Valery Krizhanovsky,Monica Yon,Monica Yon,Ross A. Dickins,Stephen Hearn,Janelle Simon,Janelle Simon,Cornelius Miething,Herman T. Yee,Lars Zender,Scott W. Lowe,Scott W. Lowe +11 more
TL;DR: In this paper, the authors show that senescent cells accumulate in murine livers treated to produce fibrosis, a precursor pathology to cirrhosis, derived primarily from activated hepatic stellate cells, which initially proliferate in response to liver damage and produce the extracellular matrix.
Journal ArticleDOI
Long term prognosis of fatty liver: risk of chronic liver disease and death
Sanne Dam-Larsen,Maria-Benedicte Franzmann,I B Andersen,Per Christoffersen,L B Jensen,T. I. A. Sørensen,Ulrik Becker,Flemming Bendtsen +7 more
TL;DR: Patients with type 1 non-alcoholic fatty liver disease have a benign clinical course without excess mortality, as revealed in a cohort diagnosed with pure fatty liver without inflammation.
Journal ArticleDOI
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
TL;DR: The histopathological features of NAFLD/NASH are reviewed and interobserver agreement for evaluating the extent of steatosis and fibrosis is high, agreement is low for intralobular and portal inflammation.
Journal ArticleDOI
Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas.
Masahisa Jinushi,Tetsuo Takehara,Tomohide Tatsumi,Naoki Hiramatsu,Ryotaro Sakamori,Shinjiro Yamaguchi,Norio Hayashi +6 more
TL;DR: In vitro experiments revealed that sMICA derived from advanced HCC was responsible for down-modulation of NKG2D expression and NK cell functions and may serve as a tumor evasion mechanism by negatively modulating both innate and adaptive immunity.
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