Malathion resistance and prevalence of the malathion carboxylesterase mechanism in populations of mosquito vectors of disease in Sri Lanka
Reads0
Chats0
TLDR
Resistance among the Anophelesspp.Abstract:
OBJECTIVE: To determine the levels of malathion resistance and prevalence of the malathion carboxylesterase mechanism among mosquitoes in Sri Lanka. METHODS: Bioassays were carried out using WHO-recommended methods on samples of the following Sri Lankan mosquito vectors: Culex quinquefasciatus, C. tritaeniorhynchus, C. gelidus; Anopheles culicifacies B, A. subpictus; Aedes aegypti and A. albopictus. FINDINGS: Malathion-specific carboxylesterase mechanisms were found in A. culicifacies and A. subpictus, both giving high rates of insecticide metabolism. In contrast, malathion resistance in C. quinquefasciatus and C. tritaeniorhynchus is linked to broad-spectrum resistance to organophosphorus compounds due to elevated levels of esterases that sequester malaoxon, but are unable to metabolize malathion. CONCLUSIONS: Resistance among the Anopheles spp. must have occurred as a direct result of antimalarial activities, since malathion use in Sri Lanka is limited to public health treatments. In contrast, resistance among Culex spp. has resulted from large-scale use of the organophosphorus insecticide group as larvicides for filariasis control and on rice paddy, where C. tritaeniorhynchus predominantly breeds, for agricultural purposes.read more
Citations
More filters
Biochemical genetics and genomics of insect esterases
TL;DR: This article reviews the biochemistry and genetics of insect esterases, focusing mainly on developments, from a genomics perspective and the bulk of it is organized around the major clades of insectEsterases as revealed by the comparative genomic analysis.
Journal ArticleDOI
Global status of DDT and its alternatives for use in vector control to prevent disease.
TL;DR: Support is needed for integrated and multipartner strategies of vector control and for the continued development of new technologies as sustainable alternatives to reliance on DDT.
Book ChapterDOI
Biochemical Genetics and Genomics of Insect Esterases
TL;DR: The Comprehensive Molecular Insect Science (CMIIS) as discussed by the authors is a complete reference encompassing important developments and achievements in modern insect science, including reviews on the ecdysone receptor, lipocalins, and bacterial toxins.
Book ChapterDOI
Distribution, Mechanisms, Impact and Management of Insecticide Resistance in Malaria Vectors: A Pragmatic Review
Vincent Corbel,Raphael N’Guessan +1 more
TL;DR: The current level, distribution and mechanisms of insecticide resistance in malaria vectors and their impact on the efficacy of vector control interventions are reviewed and strategies to prevent and/or delay the spread of insecticides resistance in natural mosquito populations are discussed.
Journal ArticleDOI
Widespread distribution of a newly found point mutation in voltage-gated sodium channel in pyrethroid-resistant Aedes aegypti populations in Vietnam.
Hitoshi Kawada,Yukiko Higa,Osamu Komagata,Shinji Kasai,Takashi Tomita,Nguyen Thi Yen,Luu Lee Loan,Rodrigo A. P. Sánchez,Masahiro Takagi +8 more
TL;DR: The overall percentage of homozygous F1269C seems to remain low (7.4%) in the present situation, however, extensive and uncontrolled frequent use of photostable pyrethroids might be a strong selection pressure for this mutation to cause serious problems in the control of dengue fever in Vietnam.
References
More filters
Journal ArticleDOI
Amplification of an esterase gene is responsible for insecticide resistance in a California Culex mosquito.
C Mouches,Nicole Pasteur,Jean-Baptiste Bergé,Olivier Hyrien,Michel Raymond,B R de Saint Vincent,M de Silvestri,George P. Georghiou +7 more
TL;DR: The finding that selection by pesticides may result in the amplification of genes encoding detoxifying enzymes in whole, normally developed, reproducing insects emphasizes the biological importance of this mechanism and opens new areas of investigation in pesticide resistance management.
Journal ArticleDOI
Mosquito carboxylesterases: a review of the molecular biology and biochemistry of a major insecticide resistance mechanism.
TL;DR: The classification of the mosquito esterases in the context of classical esterase nomenclature is covered and implications of information on the ester enzyme amplicons are discussed in relation to the evolution and migration of insecticide resistance in Culex.
Journal Article
Heme peroxidase activity measured in single mosquitoes identifies individuals expressing an elevated oxidase for insecticide resistance
TL;DR: A simple, rapid, microplate-based assay that indirectly measures the differences in oxidase levels between individual susceptible, resistant, or induced mosquitoes is described.
Journal ArticleDOI
Two different amino acid substitutions in the ali-esterase, E3, confer alternative types of organophosphorus insecticide resistance in the sheep blowfly, Lucilia cuprina
TL;DR: A model in which the malathion carboxylesterase activity of the E3-Leu 251 enzyme is enhanced in vivo by its OP hydrolase activity is presented, which is consistent with the OP cross-resistance patterns.
Journal ArticleDOI
A possible novel link between organophosphorus and DDT insecticide resistance genes in Anopheles: Supporting evidence from fenitrothion metabolism studies
TL;DR: Fenitrothion metabolism studies on a multiple organophosphorus resistant strain of Anopheles subpictus from Sri Lanka indicated that oxidases and glutathione S -transferases play a major role in the detoxication of this insecticide.