Mammalian non-classical major histocompatibility complex I and its receptors: Important contexts of gene, evolution, and immunity
B.M. Pratheek,Tapas Kumar Nayak,S. Sahoo,Prafulla K. Mohanty,Soma Chattopadhyay,Ntiya G Chakraborty,Subhasis Chattopadhyay +6 more
TLDR
This review highlights the new updates of the mammalian nonclassical MHC-I molecules in terms of their gene organization, evolutionary perspective and their role in immunity.Abstract:
The evolutionary conserved, less-polymorphic, nonclassical major histocompatibility complex (MHC) class I molecules: Qa-1 and its human homologue human leukocyte antigen-E (HLA-E) along with HLA-F, G and H cross-talk with the T-cell receptors and also interact with natural killer T-cells and other lymphocytes. Moreover, these nonclassical MHC molecules are known to interact with CD94/NKG2 heterodimeric receptors to induce immune responses and immune regulations. This dual role of Qa-1/HLA-E in terms of innate and adaptive immunity makes them more interesting. This review highlights the new updates of the mammalian nonclassical MHC-I molecules in terms of their gene organization, evolutionary perspective and their role in immunity.read more
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Natural Killer Cells: Development, Maturation, and Clinical Utilization
Alex M. Abel,Alex M. Abel,Chao Yang,Chao Yang,Monica S. Thakar,Monica S. Thakar,Subramaniam Malarkannan +6 more
TL;DR: Recent advances made in the understanding of how NK cells develop, mature, and their potential translational use in the clinic are summarized.
Journal ArticleDOI
Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases.
Christos Argyropoulos,Shan Shan Chen,Yue Harn Ng,Maria-Eleni Roumelioti,Kamran Shaffi,Pooja Singh,Antonios H. Tzamaloukas,Antonios H. Tzamaloukas +7 more
TL;DR: The role of beta-2 microglobulin (β2M) as a biomarker in patients with chronic kidney disease and end-stage renal disease is revisited and emerging proteomic data suggesting that β2M is a promising marker of chronic allograft nephropathy is noted.
Journal ArticleDOI
HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8+ T lymphocytes
Marloes J. M. Gooden,Margit H Lampen,Ekaterina S. Jordanova,Ninke Leffers,J. Baptist Trimbos,Sjoerd H. van der Burg,Hans W. Nijman,Thorbald van Hall +7 more
TL;DR: This article investigated HLA-E protein expression on tissue sections of 420 ovarian and cervical cancers and found equal or higher levels than normal counterpart epithelia in 80% of the tumors.
Journal ArticleDOI
Classical and non-classical HLA class I aberrations in primary cervical squamous- and adenocarcinomas and paired lymph node metastases
Debbie M. Ferns,A. Marijne Heeren,Sanne Samuels,Maaike C G Bleeker,Tanja D. de Gruijl,Gemma G. Kenter,Gemma G. Kenter,Ekaterina S. Jordanova +7 more
TL;DR: These results strengthen the idea of tumor immune escape variants leading to metastasis and warrant further analysis of HLA expression as a biomarker for patient selection for CTL- and NK- cell based immunotherapeutic intervention.
Journal ArticleDOI
HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins.
Adi Reches,Daphna Nachmani,Orit Berhani,Alexandra Duev-Cohen,Dorin Shreibman,Yael Ophir,Barbara Seliger,Ofer Mandelboim +7 more
TL;DR: It is demonstrated that HNRNPR binds MHC class I mRNAs in their 3′ untranslated regions and enhances their stability and consequently their expression, and modulates the cytotoxic activity of NK cells.
References
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Hans-Gustaf Ljunggren,Klas Kärre +1 more
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Journal ArticleDOI
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Veronique M. Braud,David S.J. Allan,Christopher A. O’Callaghan,Kalle Söderström,Annalisa D'Andrea,Graham S. Ogg,Sasha Lazetic,Neil Thomas Young,John I. Bell,Joseph H. Phillips,Lewis L. Lanier,Andrew J. McMichael +11 more
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Journal ArticleDOI
MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function
TL;DR: The specificity and function of mouse NK1 T cells are reviewed, the relationship of this lineage to mainstream T cells and NK cells is discussed, and the novel regulatory pathway, which straddles the innate and the adaptive immune systems, is discussed.
Journal ArticleDOI
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