Mammographic Density Phenotypes and Risk of Breast Cancer: A Meta-analysis
Andreas Pettersson,Rebecca E. Graff,Giske Ursin,Isabel dos Santos Silva,Valerie McCormack,Laura Baglietto,Laura Baglietto,Celine M. Vachon,Marije F. Bakker,Marije F. Bakker,Graham G. Giles,Graham G. Giles,Graham G. Giles,Kee Seng Chia,Kamila Czene,Louise Eriksson,Per Hall,Mikael Hartman,Ruth M. L. Warren,Gregory Hislop,Anna M. Chiarelli,John L. Hopper,Kavitha Krishnan,Kavitha Krishnan,Jingmei Li,Qing Li,Ian S Pagano,Bernard Rosner,Chia Siong Wong,Christopher G. Scott,Jennifer Stone,Gertraud Maskarinec,Norman F. Boyd,Carla H. van Gils,Carla H. van Gils,Rulla M. Tamimi +35 more
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TLDR
It is suggested that percentage dense area is a stronger breast cancer risk factor than absolute dense area, but it is unclear whether the association is independent ofabsolute dense area.Abstract:
Results Among premenopausal women (n = 1776 case patients; n = 2834 control subjects), summary odds ratios were 1.37 (95% CI = 1.29 to 1.47) for absolute dense area, 0.78 (95% CI = 0.71 to 0.86) for absolute nondense area, and 1.52 (95% CI = 1.39 to 1.66) for percentage dense area when pooling estimates adjusted for age, body mass index, and parity. Corresponding odds ratios among postmenopausal women (n = 6643 case patients; n = 11 187 control subjects) were 1.38 (95% CI = 1.31 to 1.44), 0.79 (95% CI = 0.73 to 0.85), and 1.53 (95% CI = 1.44 to 1.64). After additional adjustment for absolute dense area, associations between absolute nondense area and breast cancer became attenuated or null in several studies and summary odds ratios became 0.82 (95% CI = 0.71 to 0.94; Pheterogeneity = .02) for premenopausal and 0.85 (95% CI = 0.75 to 0.96; Pheterogeneity < .01) for postmenopausal women. Conclusions The results suggest that percentage dense area is a stronger breast cancer risk factor than absolute dense area. Absolute nondense area was inversely associated with breast cancer risk, but it is unclear whether the association is independent of absolute dense area.read more
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The 2017 hormone therapy position statement of The North American Menopause Society.
JoAnn V. Pinkerton,Fernando Sánchez Aguirre,Jennifer Blake,Felicia Cosman,Howard N. Hodis,Susan Hoffstetter,Andrew M. Kaunitz,Sheryl A. Kingsberg,Pauline M. Maki,JoAnn E. Manson,Polly Marchbanks,Michael R. McClung,Lila E. Nachtigall,Lawrence M. Nelson,Diane Todd Pace,Robert L. Reid,Phillip M. Sarrel,Jan L. Shifren,Cynthia A. Stuenkel,Wulf H. Utian +19 more
TL;DR: Hormone therapy (HT) remains the most effective treatment for vasomotor symptoms and the genitourinary syndrome of menopause (GSM) and has been shown to prevent bone loss and fracture.
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Mammographic density and the risk and detection of breast cancer
TL;DR: The conclusion of the current study was that the frequency of screening might be dependent on breast density and in such cases diagnostic techniques such as “digital mammography, ultra sonography and magnetic resonance imaging” may prove to be better detection tools.
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Risk determination and prevention of breast cancer
Anthony Howell,Annie S. Anderson,Robert Clarke,Stephen W. Duffy,D. Gareth Evans,Montserat Garcia-Closas,Andy J. Gescher,Timothy J. Key,John M. Saxton,Michelle Harvie +9 more
TL;DR: Recent data is summarized on newer approaches to risk prediction, available approaches to prevention, how new approaches may be made, and the difficult problem of using what the authors already know to prevent breast cancer in populations.
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An overview of mammographic density and its association with breast cancer.
Shayan Nazari,Pinku Mukherjee +1 more
TL;DR: The goal of this review is to highlight the current molecular understanding of MD, its association with breast cancer risk, the demographics pertaining to MD, and the environmental factors that modulate MD.
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Population-Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer.
Natalie J. Engmann,Marzieh K Golmakani,Diana L. Miglioretti,Diana L. Miglioretti,Brian L. Sprague,Karla Kerlikowske +5 more
TL;DR: Most women with breast cancer have at least 1 breast cancer risk factor routinely documented at the time of mammography, and more than half of premenopausal and postmenopausal breast cancers are explained by these factors.
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