Journal ArticleDOI
Management of gastric cancer in Asia: resource-stratified guidelines
Lin Shen,Yan Shen Shan,Huang Ming Hu,Timothy J. Price,Bhawna Sirohi,Kun-Huei Yeh,Yi-Hsin Yang,Takeshi Sano,Han-Kwang Yang,Xiaotian Zhang,Sook Ryun Park,Masashi Fujii,Yoon-Koo Kang,Li-Tzong Chen,Li-Tzong Chen +14 more
TLDR
This work aims to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries, using the categories of basic, limited, enhanced, and maximum level.Abstract:
Summary Gastric cancer is the fourth most common cancer globally, and is the second most common cause of death from cancer worldwide. About three-quarters of newly diagnosed cases in 2008 were from Asian countries. With a high mortality-to-incidence ratio, management of gastric cancer is challenging. We discuss evidence for optimum management of gastric cancer in aspects of screening and early detection, diagnosis, and staging; endoscopic and surgical intervention; and the concepts of perioperative, postoperative, and palliative chemotherapy and use of molecularly targeted therapy. Recommendations are formulated on the basis of the framework provided by the Breast Health Global Initiative, using the categories of basic, limited, enhanced, and maximum level. We aim to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries.read more
Citations
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MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling
TL;DR: The present study suggests that miR-140-5p directly targets and negatively regulates THY1 expression and inhibits activation of the Notch signaling pathway, whereby the up-regulation of miR -140- 5p inhibits development of GC, highlighting the promise of miP-140 -5p as a potential target for GC treatment.
Journal ArticleDOI
Family history of cancer in first-degree relatives and risk of gastric cancer and its precursors in a Western population.
Minkyo Song,M. Constanza Camargo,Stephanie J. Weinstein,Ana F. Best,Satu Männistö,Demetrius Albanes,Charles S. Rabkin +6 more
TL;DR: Gastric cancer risk was associated with gastric cancer history in first-degree relatives overall and with low pepsinogen, a marker of gastric atrophy, a risk factor for developing this malignancy.
Journal ArticleDOI
Roles of competing endogenous RNAs in gastric cancer
TL;DR: Recent findings on the roles of ceRNAs in gastric carcinogenesis are discussed, and the ceRNA regulatory mechanism may participate in this pathogenic process.
Journal ArticleDOI
Amido-Bridged Nucleic Acid-Modified Antisense Oligonucleotides Targeting SYT13 to Treat Peritoneal Metastasis of Gastric Cancer.
Mitsuro Kanda,Yuuya Kasahara,Dai Shimizu,Takashi Miwa,Shinichi Umeda,Koichi Sawaki,Shunsuke Nakamura,Yasuhiro Kodera,Satoshi Obika +8 more
TL;DR: Intra-abdominal administration of AmNA-modified anti-SYT13 ASOs represents a promising strategy for treating peritoneal metastasis of gastric cancer and it was found that SYT13 interfered with focal adhesion kinase (FAK)-mediated intracellular signals.
Journal ArticleDOI
Overexpression of TRIB3 promotes angiogenesis in human gastric cancer
Shaoting Dong,Jianling Xia,Hongqiang Wang,Li Sun,Zhenzhen Wu,Jianping Bin,Yulin Liao,Nailin Li,Wangjun Liao +8 more
TL;DR: It is found that overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with GC, and the findings indicate that TRIB 3 is a promising target for anti‑angiogenic therapy in GC.
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