Journal ArticleDOI
Management of gastric cancer in Asia: resource-stratified guidelines
Lin Shen,Yan Shen Shan,Huang Ming Hu,Timothy J. Price,Bhawna Sirohi,Kun-Huei Yeh,Yi-Hsin Yang,Takeshi Sano,Han-Kwang Yang,Xiaotian Zhang,Sook Ryun Park,Masashi Fujii,Yoon-Koo Kang,Li-Tzong Chen,Li-Tzong Chen +14 more
TLDR
This work aims to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries, using the categories of basic, limited, enhanced, and maximum level.Abstract:
Summary Gastric cancer is the fourth most common cancer globally, and is the second most common cause of death from cancer worldwide. About three-quarters of newly diagnosed cases in 2008 were from Asian countries. With a high mortality-to-incidence ratio, management of gastric cancer is challenging. We discuss evidence for optimum management of gastric cancer in aspects of screening and early detection, diagnosis, and staging; endoscopic and surgical intervention; and the concepts of perioperative, postoperative, and palliative chemotherapy and use of molecularly targeted therapy. Recommendations are formulated on the basis of the framework provided by the Breast Health Global Initiative, using the categories of basic, limited, enhanced, and maximum level. We aim to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries.read more
Citations
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Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis.
TL;DR: In this article, the authors showed that curcumin treatment led to a decrease in circ_0056618 level in GC cells and miR-194-5p was reduced in GC tissues and cells.
Journal ArticleDOI
miRNAs derived from plasma small extracellular vesicles predict organo-tropic metastasis of gastric cancer
Cheng Zhang,Jing Yang,Yang Chen,Fang-Qing Jiang,Haiyan Liao,Xiang Liu,Yuan Wang,Guanyi Kong,Xiaotian Zhang,Jian Li,Jing Gao,Linfanf Shen +11 more
TL;DR: In this article , small extracellular vesicle (sEV)-derived miRNAs were used to predict the organo-tropic metastasis of gastric cancer.
Journal ArticleDOI
Low abundance of TFPI-2 by both promoter methylation and miR-27a-3p regulation is linked with poor clinical outcome in gastric cancer
TL;DR: The present study aimed to improve the understanding of the oncogenic properties of TFPI‐2 in gastric cancer by studying its role in tumor suppressor role and tumorigenicity.
Journal ArticleDOI
ESD Around the World: United States
TL;DR: Simplification of technique, modification of tools and materials, and improved availability of training opportunities are essential in order to accelerate the adoption of ESD in the United States.
Journal ArticleDOI
Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways.
Zuhua Chen,Zhentao Liu,Wenwen Huang,Zhongwu Li,Jianling Zou,Jingyuan Wang,Xiaoting Lin,Beifang Li,Dongshao Chen,Yanting Hu,Jiafu Ji,Jing Gao,Lin Shen +12 more
TL;DR: For the first time, the antitumor activity of gimatecan in GC is shown via suppressing AKT and ERK pathway and activating JNK2 and p38 MAPK pathway, which indicated that gimate can might be an alternative to irinotecan in the treatment of GC.
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