Journal ArticleDOI
Management of gastric cancer in Asia: resource-stratified guidelines
Lin Shen,Yan Shen Shan,Huang Ming Hu,Timothy J. Price,Bhawna Sirohi,Kun-Huei Yeh,Yi-Hsin Yang,Takeshi Sano,Han-Kwang Yang,Xiaotian Zhang,Sook Ryun Park,Masashi Fujii,Yoon-Koo Kang,Li-Tzong Chen,Li-Tzong Chen +14 more
TLDR
This work aims to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries, using the categories of basic, limited, enhanced, and maximum level.Abstract:
Summary Gastric cancer is the fourth most common cancer globally, and is the second most common cause of death from cancer worldwide. About three-quarters of newly diagnosed cases in 2008 were from Asian countries. With a high mortality-to-incidence ratio, management of gastric cancer is challenging. We discuss evidence for optimum management of gastric cancer in aspects of screening and early detection, diagnosis, and staging; endoscopic and surgical intervention; and the concepts of perioperative, postoperative, and palliative chemotherapy and use of molecularly targeted therapy. Recommendations are formulated on the basis of the framework provided by the Breast Health Global Initiative, using the categories of basic, limited, enhanced, and maximum level. We aim to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries.read more
Citations
More filters
Journal ArticleDOI
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial
Yoon-Koo Kang,Narikazu Boku,Taroh Satoh,Min Hee Ryu,Yee Chao,Ken Kato,Hyun Cheol Chung,Jen-Shi Chen,Kei Muro,Won Ki Kang,Kun-Huei Yeh,Takaki Yoshikawa,Sang Cheul Oh,Li Yuan Bai,Takao Tamura,Keun Wook Lee,Yasuo Hamamoto,Jong Gwang Kim,Keisho Chin,Do Youn Oh,Keiko Minashi,Jae Yong Cho,Masahiro Tsuda,Li-Tzong Chen,Li-Tzong Chen +24 more
TL;DR: In this phase 3 study, the survival benefits indicate that nivolumab might be a new treatment option for heavily pretreated patients with advanced gastric or gastro-oesophageal junction cancer.
Journal ArticleDOI
Cause-specific mortality for 240 causes in China during 1990-2013: a systematic subnational analysis for the Global Burden of Disease Study 2013.
Maigeng Zhou,Haidong Wang,Jun Zhu,Wanqing Chen,Linhong Wang,Shiwei Liu,Yichong Li,Lijun Wang,Yunning Liu,Peng Yin,Jiangmei Liu,Shicheng Yu,Feng Tan,Ryan M Barber,Matthew M Coates,Daniel Dicker,Maya S Fraser,Diego Gonzalez-Medina,Hannah Hamavid,Yuantao Hao,Guoqing Hu,Guohong Jiang,Haidong Kan,Alan D. Lopez,Michael R. Phillips,Michael R. Phillips,Jun She,Theo Vos,Xia Wan,Gelin Xu,Lijing L. Yan,Chuanhua Yu,Yong Zhao,Yingfeng Zheng,Xiaonong Zou,Mohsen Naghavi,Yu Wang,Christopher J L Murray,Gonghuan Yang,Xiaofeng Liang +39 more
TL;DR: The most common non-communicable diseases, including ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and cancers (liver, stomach, and lung), contributed much more to YLLs in 2013 compared with 1990, and road injuries have become a top ten cause of death in all provinces in mainland China.
Journal ArticleDOI
Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype
Ana Ferro,Bárbara Peleteiro,Matteo Malvezzi,Cristina Bosetti,Paola Bertuccio,Fabio Levi,Eva Negri,Carlo La Vecchia,Carlo La Vecchia,Nuno Lunet +9 more
TL;DR: Despite the favourable mortality trends worldwide, in some countries the declines are becoming less marked, and the predictions for 2015 show that a levelling off of rates is expected in the USA and a few other countries.
Journal ArticleDOI
Effectiveness of the Korean National Cancer Screening Program in Reducing Gastric Cancer Mortality
Jae Kwan Jun,Kui Son Choi,Hoo Yeon Lee,Mina Suh,Boyoung Park,Seung Hoon Song,Kyu-Won Jung,Chan Wha Lee,Il Ju Choi,Eun Cheol Park,Dukhyoung Lee +10 more
TL;DR: Within the Korean National Cancer Screening Program, patients who received an upper endoscopy were less likely to die from gastric cancer; no associations were found for UGI series.
Journal ArticleDOI
Genetics of gastric cancer.
Mairi H. McLean,Emad M. El-Omar +1 more
TL;DR: The genetic basis of gastric cancer will offer insights into its pathogenesis, help identify new biomarkers and novel treatment targets, aid prognostication and could be central to developing individualized treatment strategies in the future.
References
More filters
Journal ArticleDOI
Phase II study of neoadjuvant chemotherapy and extended surgery for locally advanced gastric cancer.
Takaki Yoshikawa,Mitsuru Sasako,Seiichiro Yamamoto,Takeshi Sano,Hiroshi Imamura,Kazumasa Fujitani,H Oshita,S Ito,Y. Kawashima,Norimasa Fukushima +9 more
TL;DR: This trial explored the safety and efficacy of preoperative chemotherapy followed by extended surgery in the management of locally advanced gastric adenocarcinoma.
Journal ArticleDOI
CT and PET in Stomach Cancer: Preoperative Staging and Monitoring of Response to Therapy
Joon Seok Lim,Mijin Yun,Myeong-Jin Kim,Woo Jin Hyung,Mi-Suk Park,Jin-Young Choi,Tae Sung Kim,Jong Doo Lee,Sung Hoon Noh,Ki Whang Kim +9 more
TL;DR: The combined use of CT and PET can be helpful in the preoperative staging of stomach cancer and in the therapeutic monitoring of affected patients.
Journal ArticleDOI
Longterm outcomes after endoscopic mucosal resection for early gastric cancer.
Noriya Uedo,Hiroyasu Iishi,Masaharu Tatsuta,Ryu Ishihara,Koji Higashino,Yoji Takeuchi,Kazuho Imanaka,Takuya Yamada,Sachiko Yamamoto,Shunsuke Yamamoto,Hideaki Tsukuma,Shingo Ishiguro +11 more
TL;DR: En bloc EMR ensured an excellent prognosis, and should be the first choice of treatment in patients with small differentiated mucosal EGC, which is the most common type of gastric cancer.
Journal ArticleDOI
Randomized phase III study comparing the efficacy and safety of irinotecan plus S-1 with S-1 alone as first-line treatment for advanced gastric cancer (study GC0301/TOP-002)
Hiroyuki Narahara,Hiroyasu Iishi,Hiroshi Imamura,Akira Tsuburaya,Keisho Chin,Haruhiko Imamoto,Taito Esaki,Hiroshi Furukawa,Chikuma Hamada,Yuh Sakata +9 more
TL;DR: Although IRI-S achieved longer median survival than S-1 monotherapy and was well tolerated, it did not show significant superiority in this study.
Journal ArticleDOI
Early gastric cancer: lymph node metastasis starts with deep mucosal infiltration.
Arnulf H. Hölscher,Uta Drebber,Stefan Mönig,C. Schulte,Daniel Vallböhmer,Elfriede Bollschweiler +5 more
TL;DR: Endoscopic mucosectomy in m3 carcinoma is questionable and in all submucosal carcinomas and lesions ≥2 cm it is not indicated, and the size of tumor showed independent influence on the rate of lymph node metastasis.