Journal ArticleDOI
Management of gastric cancer in Asia: resource-stratified guidelines
Lin Shen,Yan Shen Shan,Huang Ming Hu,Timothy J. Price,Bhawna Sirohi,Kun-Huei Yeh,Yi-Hsin Yang,Takeshi Sano,Han-Kwang Yang,Xiaotian Zhang,Sook Ryun Park,Masashi Fujii,Yoon-Koo Kang,Li-Tzong Chen,Li-Tzong Chen +14 more
TLDR
This work aims to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries, using the categories of basic, limited, enhanced, and maximum level.Abstract:
Summary Gastric cancer is the fourth most common cancer globally, and is the second most common cause of death from cancer worldwide. About three-quarters of newly diagnosed cases in 2008 were from Asian countries. With a high mortality-to-incidence ratio, management of gastric cancer is challenging. We discuss evidence for optimum management of gastric cancer in aspects of screening and early detection, diagnosis, and staging; endoscopic and surgical intervention; and the concepts of perioperative, postoperative, and palliative chemotherapy and use of molecularly targeted therapy. Recommendations are formulated on the basis of the framework provided by the Breast Health Global Initiative, using the categories of basic, limited, enhanced, and maximum level. We aim to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries.read more
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Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial
Yoon-Koo Kang,Narikazu Boku,Taroh Satoh,Min Hee Ryu,Yee Chao,Ken Kato,Hyun Cheol Chung,Jen-Shi Chen,Kei Muro,Won Ki Kang,Kun-Huei Yeh,Takaki Yoshikawa,Sang Cheul Oh,Li Yuan Bai,Takao Tamura,Keun Wook Lee,Yasuo Hamamoto,Jong Gwang Kim,Keisho Chin,Do Youn Oh,Keiko Minashi,Jae Yong Cho,Masahiro Tsuda,Li-Tzong Chen,Li-Tzong Chen +24 more
TL;DR: In this phase 3 study, the survival benefits indicate that nivolumab might be a new treatment option for heavily pretreated patients with advanced gastric or gastro-oesophageal junction cancer.
Journal ArticleDOI
Cause-specific mortality for 240 causes in China during 1990-2013: a systematic subnational analysis for the Global Burden of Disease Study 2013.
Maigeng Zhou,Haidong Wang,Jun Zhu,Wanqing Chen,Linhong Wang,Shiwei Liu,Yichong Li,Lijun Wang,Yunning Liu,Peng Yin,Jiangmei Liu,Shicheng Yu,Feng Tan,Ryan M Barber,Matthew M Coates,Daniel Dicker,Maya S Fraser,Diego Gonzalez-Medina,Hannah Hamavid,Yuantao Hao,Guoqing Hu,Guohong Jiang,Haidong Kan,Alan D. Lopez,Michael R. Phillips,Michael R. Phillips,Jun She,Theo Vos,Xia Wan,Gelin Xu,Lijing L. Yan,Chuanhua Yu,Yong Zhao,Yingfeng Zheng,Xiaonong Zou,Mohsen Naghavi,Yu Wang,Christopher J L Murray,Gonghuan Yang,Xiaofeng Liang +39 more
TL;DR: The most common non-communicable diseases, including ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and cancers (liver, stomach, and lung), contributed much more to YLLs in 2013 compared with 1990, and road injuries have become a top ten cause of death in all provinces in mainland China.
Journal ArticleDOI
Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype
Ana Ferro,Bárbara Peleteiro,Matteo Malvezzi,Cristina Bosetti,Paola Bertuccio,Fabio Levi,Eva Negri,Carlo La Vecchia,Carlo La Vecchia,Nuno Lunet +9 more
TL;DR: Despite the favourable mortality trends worldwide, in some countries the declines are becoming less marked, and the predictions for 2015 show that a levelling off of rates is expected in the USA and a few other countries.
Journal ArticleDOI
Effectiveness of the Korean National Cancer Screening Program in Reducing Gastric Cancer Mortality
Jae Kwan Jun,Kui Son Choi,Hoo Yeon Lee,Mina Suh,Boyoung Park,Seung Hoon Song,Kyu-Won Jung,Chan Wha Lee,Il Ju Choi,Eun Cheol Park,Dukhyoung Lee +10 more
TL;DR: Within the Korean National Cancer Screening Program, patients who received an upper endoscopy were less likely to die from gastric cancer; no associations were found for UGI series.
Journal ArticleDOI
Genetics of gastric cancer.
Mairi H. McLean,Emad M. El-Omar +1 more
TL;DR: The genetic basis of gastric cancer will offer insights into its pathogenesis, help identify new biomarkers and novel treatment targets, aid prognostication and could be central to developing individualized treatment strategies in the future.
References
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A systematic review and meta-analysis of the utility of EUS for preoperative staging for gastric cancer
Roberta Cardoso,Natalie G. Coburn,Rajini Seevaratnam,Rinku Sutradhar,Laércio Gomes Lourenço,Alyson L. Mahar,Calvin Law,Elaine Yong,Jill Tinmouth +8 more
TL;DR: EUS is a moderately accurate technique that seems to describeadvanced T stage (T3 and T4) better than N or less advanced T stage and Stratifying by EUS annual volume did not affect EUS performance in staging gastric cancer.
Journal ArticleDOI
Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer – Differential treatment strategies for subtypes of early gastroesophageal cancer
Manfred P. Lutz,John Zalcberg,Michel Ducreux,Jaffer A. Ajani,William H. Allum,Daniela Aust,Yung-Jue Bang,Stefano Cascinu,Arnulf H. Hölscher,Janusz Jankowski,Edwin P.M. Jansen,Ralf Kisslich,Florian Lordick,Christophe Mariette,Markus Moehler,Tsuneo Oyama,Arnaud Roth,Josef Rueschoff,Thomas Ruhstaller,Raquel Seruca,Michael Stahl,Florian Sterzing,Eric Van Cutsem,Ate van der Gaast,J. Jan B. van Lanschot,Marc Ychou,Florian Otto +26 more
TL;DR: The 1st St. Gallen EORTC Gastrointestinal Cancer Conference 2012 Expert Panel clearly differentiated treatment and staging recommendations for the various gastroesophageal cancers.
Journal ArticleDOI
Randomized controlled trial of adjuvant uracil–tegafur versus surgery alone for serosa‐negative, locally advanced gastric cancer
T. Nakajima,Taira Kinoshita,Atsushi Nashimoto,M. Sairenji,Toshiharu Yamaguchi,J. Sakamoto,T. Fujiya,T. Inada,Mitsuru Sasako,Yasuo Ohashi +9 more
TL;DR: This prospective randomized study compared the survival of patients with tumour node metastasis (TNM) stage T2 N1–2 gastric cancer treated by gast rectomy alone or gastrectomy followed by uracil–tegafur.