Journal ArticleDOI
Management of gastric cancer in Asia: resource-stratified guidelines
Lin Shen,Yan Shen Shan,Huang Ming Hu,Timothy J. Price,Bhawna Sirohi,Kun-Huei Yeh,Yi-Hsin Yang,Takeshi Sano,Han-Kwang Yang,Xiaotian Zhang,Sook Ryun Park,Masashi Fujii,Yoon-Koo Kang,Li-Tzong Chen,Li-Tzong Chen +14 more
TLDR
This work aims to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries, using the categories of basic, limited, enhanced, and maximum level.Abstract:
Summary Gastric cancer is the fourth most common cancer globally, and is the second most common cause of death from cancer worldwide. About three-quarters of newly diagnosed cases in 2008 were from Asian countries. With a high mortality-to-incidence ratio, management of gastric cancer is challenging. We discuss evidence for optimum management of gastric cancer in aspects of screening and early detection, diagnosis, and staging; endoscopic and surgical intervention; and the concepts of perioperative, postoperative, and palliative chemotherapy and use of molecularly targeted therapy. Recommendations are formulated on the basis of the framework provided by the Breast Health Global Initiative, using the categories of basic, limited, enhanced, and maximum level. We aim to provide a stepwise strategy for management of gastric cancer applicable to different levels of health-care resources in Asian countries.read more
Citations
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SOD2 rs4880 CT/CC genotype to predict poor survival for Chinese gastric cancer patients received platinum and fluorouracil based adjuvant chemotherapy.
TL;DR: In this paper, the authors investigated the clinical associations of two single nucleotide polymorphisms of SOD2 and GSTP1 in stage II-III postoperative gastric cancer patients.
Journal ArticleDOI
GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway
Xiao-Xin Zhang,Bo Ni,Qing Li,Li-Peng Hu,Shu-Heng Jiang,Rong-Kun Li,Guang-Ang Tian,Lili Zhu,Jun Li,Xueli Zhang,Yan-Li Zhang,Xiao-Mei Yang,Qin Yang,Ya-Hui Wang,Chunchao Zhu,Zhigang Zhang +15 more
TL;DR: GPAA1 facilitates the expression of cancer-related GPI-anchored proteins and supplies a more robust platform—the lipid raft—to promote EGFR-ERBB2 dimerization, which further contributes to tumour growth and metastasis and to cancer progression.
Journal ArticleDOI
MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin.
TL;DR: The results of the present study suggested that miR‑197 serves a tumour‑suppressing role in human gastric carcinogenesis and progression by regulating the MTDH/PTEN/AKT signalling pathway.
Journal ArticleDOI
RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK-cyclin D1/CDK4 pathway.
Suihai Wang,Xiaobo Wang,Yanjun Gao,Yingxia Peng,Ningning Dong,Qian Xie,Xian Zhang,Ying-Song Wu,Ming Li,Ji-Liang Li,Ji-Liang Li,Ji-Liang Li +11 more
TL;DR: It is reported that RN181 expression is significantly down‐regulated in 165 tumour tissues of gastric carcinoma (GC) versus adjacent non‐tumour tissues, and inversely associated with tumour differentiation, tumour size, clinical stage, and patient's overall survival.
Journal ArticleDOI
Inhibition of the hypoxia-induced factor-1α and vascular endothelial growth factor expression through ginsenoside Rg3 in human gastric cancer cells.
Bingqiang Li,Guofeng Qu +1 more
TL;DR: Rg3 can inhibit expression of HIF-1α and VEGF in human Gastric cancer cells and may influence abdominal implantation metastasis of gastric cancer through inhibiting its expression.
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