Journal ArticleDOI
"Manganese Extraction" Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of Nanoparticles.
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TLDR
This is the first demonstration of biodegradable inorganic mesoporous nanosystems with specific biodegrades behavior sensitive to tumor microenvironment, which also provides a feasible approach to realize the on-demand biodegradation of inorganic nanomaterials simply by "metal ion-doping" strategy, paving the way to solve the critical low-biodegradation issue of in organic drug carriers.Abstract:
Biodegradability of inorganic nanoparticles is one of the most critical issues in their further clinical translations. In this work, a novel “metal ion-doping” approach has been developed to endow inorganic mesoporous silica-based nanoparticles with tumor-sensitive biodegradation and theranostic functions, simply by topological transformation of mesoporous silica to metal-doped composite nanoformulations. “Manganese extraction” sensitive to tumor microenvironment was enabled in manganese-doped hollow mesoporous silica nanoparticles (designated as Mn-HMSNs) to fast promote the disintegration and biodegradation of Mn-HMSNs, further accelerating the breakage of Si–O–Si bonds within the framework. The fast biodegradation of Mn-HMSNs sensitive to mild acidic and reducing microenvironment of tumor resulted in much accelerated anticancer drug releasing and enhanced T1-weighted magnetic resonance imaging of tumor. A high tumor-inhibition effect was simultaneously achieved by anticancer drug delivery mediated by P...read more
Citations
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Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles.
TL;DR: The degradability and clearance timelines of various siliceous nanomaterials are compared and it is highlighted that researchers can select a specific nanommaterial in this large family according to the targeted applications and the required clearance kinetics.
Journal ArticleDOI
Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy
Han Lin,Yu Chen,Jianlin Shi +2 more
TL;DR: This tutorial review summarizes the very-recent research progress in the design and synthesis of representative nanoplatforms with intriguing nanostructures, compositions, physiochemical properties and biological behaviours for versatile catalytic chemical reaction-enabled cancer treatments, mainly by either endogenous tumour microenvironment triggering or exogenous physical irradiation.
Journal ArticleDOI
Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief.
Conghui Liu,Dongdong Wang,Shuyuan Zhang,Yaru Cheng,Fan Yang,Yi Xing,Tailin Xu,Haifeng Dong,Xueji Zhang +8 more
TL;DR: In this paper, a biodegradable cancer cell membrane-coated mesoporous copper/manganese silicate nanospheres (mCMSNs) with homotypic targeting ability to the cancer cell lines and enhanced ROS generation through singlet oxygen (1O2) production and glutathione (GSH)-activated Fenton reaction, showing excellent CDT/PDT synergistic therapeutic effects.
Journal ArticleDOI
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation.
Piao Zhu,Yu Chen,Jianlin Shi +2 more
TL;DR: High in vivo biocompatibility and easy excretion of these multifunctional nanosonosensitizers from the body have been evaluated and demonstrated to guarantee their future clinical translation, and their TME-responsive T1-weighted magnetic resonance imaging capability provides the potential for therapeutic guidance and monitoring during SDT.
Journal ArticleDOI
Switching Apoptosis to Ferroptosis: Metal–Organic Network for High-Efficiency Anticancer Therapy
Di-Wei Zheng,Di-Wei Zheng,Qi Lei,Jing-Yi Zhu,Jin-Xuan Fan,Chu-Xin Li,Cao Li,Zushun Xu,Si-Xue Cheng,Xian-Zheng Zhang +9 more
TL;DR: MON encapsulated with p53 plasmid (MON-p53) was designed to eradicate cancer cells via ferroptosis/apoptosis hybrid pathway by harnessing the recently discovered oxidative stress regulation ability of p53 and the Fenton reaction inducing capability of metal-organic network.
References
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Journal ArticleDOI
Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores
Dongyuan Zhao,Jianglin Feng,Qisheng Huo,Nicholas A. Melosh,Glenn H. Fredrickson,Bradley F. Chmelka,Galen D. Stucky +6 more
TL;DR: Use of amphiphilic triblock copolymers to direct the organization of polymerizing silica species has resulted in the preparation of well-ordered hexagonal mesoporous silica structures (SBA-15) with uniform pore sizes up to approximately 300 angstroms.
Journal ArticleDOI
Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
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Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
TL;DR: It is found that, after exposure to continuous red laser at 800 nm, malignant cells require about half the laser energy to be photothermally destroyed than the nonmalignant cells, so both efficient cancer cell diagnostics and selective photothermal therapy are realized at the same time.
Journal ArticleDOI
Stimuli-responsive nanocarriers for drug delivery
TL;DR: Recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).
Journal ArticleDOI
In vivo cancer targeting and imaging with semiconductor quantum dots
TL;DR: Sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions are achieved and a whole-body macro-illumination system with wavelength-resolved spectral imaging is integrated for efficient background removal and precise delineation of weak spectral signatures.