Mathematical Models for Immunology: Current State of the Art and Future Research Directions.
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TLDR
A review of some research areas in mathematical immunology that evolved over the last 10 years and a step-by-step approach in discussing a range of models derived to study the dynamics of both the innate and immune responses at the molecular, cellular and tissue scales.About:
This article is published in Bulletin of Mathematical Biology.The article was published on 2016-10-06 and is currently open access. It has received 141 citations till now. The article focuses on the topics: Systems immunology.read more
Citations
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Immunity to Fungal Infections
TL;DR: The nature and function of the immune response to fungi is an exciting challenge that might set the stage for new approaches to the treatment of fungal diseases, from immunotherapy to vaccines.
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Model-based assessment of the Role of Uneven Partitioning of Molecular Content on Heterogeneity and Regulation of Differentiation in CD8 T-cell Immune Responses
TL;DR: It is shown that immune response dynamics can be explained by the molecular-content heterogeneity generated by uneven partitioning at cell division, and that the degree of unevenness of molecular partitioning affects the outcome of the immune response and can promote the generation of memory cells.
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Social physics
TL;DR: The field of social physics has been a hot topic in the last few decades as mentioned in this paper , with many researchers venturing outside of their traditional domains of interest, but also taking from physics the methods that have proven so successful throughout the 19th and the 20th century.
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Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection (IRC5P.475)
Simeone Marino,Nicholas A. Cilfone,Joshua T. Mattila,JoAnne L. Flynn,Jennifer J. Linderman,Denise E. Kirschner +5 more
TL;DR: The results suggest that the dynamics of NF-κB signaling is a viable therapeutic target to promote M1 polarization early during infection and to improve outcome.
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Gene Regulatory Network Modeling of Macrophage Differentiation Corroborates the Continuum Hypothesis of Polarization States.
TL;DR: It is surmised that shifts among different phenotypes in the model mimic the hypothetical continuum of macrophage polarization, with M1 and M2 being the extremes of an uninterrupted sequence of states.
References
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Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
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Oncology Meets Immunology: The Cancer-Immunity Cycle
TL;DR: Emerging clinical data suggest that cancer immunotherapy is likely to become a key part of the clinical management of cancer and may be more effective in combination with agents that target other steps of the cycle.
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Verification, Validation, and Confirmation of Numerical Models in the Earth Sciences
TL;DR: Verification and validation of numerical models of natural systems is impossible because natural systems are never closed and because model results are always nonunique.
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The two NF-κB activation pathways and their role in innate and adaptive immunity
Giuseppina Bonizzi,Michael Karin +1 more
TL;DR: Results strongly suggest that the classical and alternative pathways to NF-κB activation have distinct regulatory functions, one that is mostly involved in innate immunity and the other in adaptive immunity.