Journal ArticleDOI
Mechanisms of hair cell death and protection.
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TLDR
The mechanisms of sensory hair cell degeneration in response to different ototoxic stimuli share a final common pathway: caspase activation, and inhibition of caspases prevents or delays hair cell death and may preserve hearing/balance function.Abstract:
Purpose of reviewSensory hair cells are mechanotransducers of the inner ear that are essential for hearing and balance. Hair cell death commonly occurs following acoustic trauma or exposure to ototoxins, such as the aminoglycoside antibiotics and the antineoplastic agent cisplatin. Loss of these innread more
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Current concepts in age-related hearing loss: Epidemiology and mechanistic pathways
TL;DR: A growing body of evidence in animal studies has suggested that cumulative effect of oxidative stress could induce damage to macromolecules such as mitochondrial DNA and that the resulting accumulation of mtDNA mutations/deletions and decline of mitochondrial function play an important role in inducing apoptosis of the cochlear cells, thereby the development of AHL.
Journal ArticleDOI
Mechanisms of noise-induced hearing loss indicate multiple methods of prevention.
Colleen G. Le Prell,Daisuke Yamashita,Shujiro Minami,Tatsuya Yamasoba,Josef M. Miller,Josef M. Miller +5 more
TL;DR: Interventions are identified that prevent noise-induced hearing loss, even with treatment onset delayed up to 3 days post-noise, and the additive effects of agents intervening at different points in the cell death pathway are assessed to optimize treatment efficacy.
Journal ArticleDOI
Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection
TL;DR: These mechanisms of aminoglycosides' antimicrobial as well as ototoxic mechanisms are reviewed in regard to established and potential future targets of hair cell protection.
Journal ArticleDOI
Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention
TL;DR: This review introduces the pathology of aminoglycoside antibiotic and the cisplatin chemotherapy classes of drugs, discusses oxidative stress in the inner ear as a primary trigger for cell damage, and delineates the ensuing cell death pathways.
Journal ArticleDOI
Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection.
TL;DR: Recent development in the understanding of the mechanisms underlying cisplatin-induced hearing loss is focused on and examples of how drug therapies have been formulated based on these mechanisms are provided.
References
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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
TL;DR: A novel protease resembling ICE (prICE) that is active in a cell-free system that reproduces the morphological and biochemical events of apoptosis in the extracts including morphological changes, cleavage of PARP and production of an oligonucleosomal ladder.
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Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development.
Y. Tony Ip,Roger J. Davis +1 more
TL;DR: The c-Jun amino-terminal kinase (JNK) group of MAP kinases has been identified in mammals and insects as discussed by the authors, indicating that this signaling pathway may contribute to inflammatory responses.