Journal ArticleDOI
Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection.
Angelo De Milito,Anna Nilsson,Kehmia Titanji,Rigmor Thorstensson,Elisabet Reizenstein,Mitsuo Narita,Sven Grutzmeier,Anders Sönnerborg,Francesca Chiodi +8 more
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TLDR
It is concluded that reduction of memory B lymphocytes in HIV-1 infection correlates with defective humoral immunity and that hyperactivated naive B cells may represent the source of abnormal IgG production in HIV -1 infection.About:
This article is published in Blood.The article was published on 2004-03-15. It has received 311 citations till now. The article focuses on the topics: Naive B cell & Hypergammaglobulinemia.read more
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B cells in HIV infection and disease
Susan Moir,Anthony S. Fauci +1 more
TL;DR: This Review focuses on advances in understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B- cell dysfunction.
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Workshop on HIV Infection and Aging: What Is Known and Future Research Directions
Rita B. Effros,Courtney V. Fletcher,Kelly A. Gebo,Jeffrey B. Halter,William R. Hazzard,Frances Mc Farland Horne,Robin Huebner,Edward N. Janoff,Amy C. Justice,Daniel R. Kuritzkes,Susan G. Nayfield,Susan Plaeger,Kenneth E. Schmader,John R. Ashworth,Christine Campanelli,Charles P. Clayton,Beth Rada,Nancy Woolard,Kevin P. High +18 more
TL;DR: Researchers in infectious diseases, geriatrics, immunology, and gerontology met to review what is known about HIV infection and aging, to identify research gaps, and to suggest high priority topics for future research.
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The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
Elin S. Gray,Maphuti C. Madiga,Tandile Hermanus,Penny L. Moore,Constantinos Kurt Wibmer,Nancy Tumba,Lise. Werner,Koleka Mlisana,Sengeziwe Sibeko,Carolyn Williamson,Salim S. Abdool Karim,Lynn Morris +11 more
TL;DR: The data indicate that fewer than 20% of HIV-1 subtype C-infected individuals develop antibodies with cross-neutralizing activity after 3 years of infection and that these antibodies target different regions of the HIV- 1 envelope, including as yet uncharacterized epitopes.
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Expansion of HIV-specific T follicular helper cells in chronic HIV infection.
Madelene Lindqvist,Jan van Lunzen,Damien Z. Soghoian,Bjorn D. Kuhl,Srinika Ranasinghe,Gregory Kranias,Michael Flanders,Samuel Cutler,Naomi Yudanin,Matthias I. Muller,Isaiah Davis,Donna L. Farber,Philip Hartjen,Friedrich Haag,Galit Alter,Julian Schulze zur Wiesch,Hendrik Streeck +16 more
TL;DR: This study suggests that high levels of HIV viremia drive the expansion of TFH cells, which in turn leads to perturbations of B cell differentiation, resulting in dysregulated antibody production.
Journal ArticleDOI
Inadequate T follicular cell help impairs B cell immunity during HIV infection
Rafael Cubas,Joseph C. Mudd,Anne Laure Savoye,Matthieu Perreau,Julien van Grevenynghe,Talibah Metcalf,Elizabeth Connick,Amie L. Meditz,Gordon J. Freeman,Guillermo Abesada-Terk,Jeffrey M. Jacobson,Ari D. Brooks,Shane Crotty,Jacob D. Estes,Giuseppe Pantaleo,Michael M. Lederman,Elias K. Haddad +16 more
TL;DR: A role for TFH cell impairment in HIV pathogenesis is demonstrated and it is suggested that enhancing their function could have a major impact on the outcome and control of HIV infection, preventing future infections and improving immune responses to vaccinations.
References
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J. Virol. Methods: Corrigendum to “Detection of stylet-borne and circulative potato viruses in aphids by duplex reverse transcription polymerase chain reaction” [59 (1996) 189]
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Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome.
TL;DR: The scope of immune dysfunction in the acquired immunodeficiency syndrome involves B cells as well as T cells, and it is concluded that the manifestations of B-cell hyperreactivity, such as hypergammaglobulinemia, seen in these patients are due to an in vivo polyclonal activation of B cells.
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Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
TL;DR: It is shown that human memory B lymphocytes proliferate and differentiate into plasma cells in response to polyclonal stimuli, such as bystander T cell help and CpG DNA, which offers a means to maintain serological memory for a human lifetime.
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Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells
TL;DR: It is reported here that human IgM+IgD+ peripheral blood (PB) B cells expressing the CD27 cell surface antigen carry mutated V genes, in contrast to CD27-negative IgM-only tonsillar germinal center and plasma cells, which may represent a general marker for memory B cells in humans.