Journal ArticleDOI
Mechanisms to explain the reverse perivascular transport of solutes out of the brain
TLDR
A mathematical model is constructed in order to test the hypothesis that periv vascular drainage of interstitial fluid and solutes out of brain tissue is driven by pulsations of the blood vessel walls, and it is shown that successful drainage may depend upon some attachment of solutes to the lining of the perivascular space, although an alternative without this requirement is also postulated.About:
This article is published in Journal of Theoretical Biology.The article was published on 2006-02-21. It has received 276 citations till now. The article focuses on the topics: Perivascular space & Interstitial fluid.read more
Citations
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Journal ArticleDOI
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Jeffrey J. Iliff,Minghuan Wang,Minghuan Wang,Yonghong Liao,Benjamin A. Plogg,Weiguo Peng,Georg Andreas Gundersen,Helene Benveniste,G. Edward Vates,Rashid Deane,Steven A. Goldman,Erlend A. Nagelhus +11 more
TL;DR: An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.
Journal ArticleDOI
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
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Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging
TL;DR: Potential mechanisms, detectable with neuroimaging, that might better fit the available evidence and provide testable hypotheses for future study are discussed.
Journal ArticleDOI
Clearance systems in the brain—implications for Alzheimer disease
Jenna M. Tarasoff-Conway,Roxana O. Carare,Ricardo S. Osorio,Lidia Glodzik,Tracy Butler,Els Fieremans,Leon Axel,Henry Rusinek,Charles Nicholson,Berislav V. Zlokovic,Blas Frangione,Kaj Blennow,Joël Ménard,Henrik Zetterberg,Thomas Wisniewski,Mony J. de Leon +15 more
TL;DR: The clearance systems of the brain as they relate to proteins implicated in AD pathology are described, with the main focus on Aβ.
Journal ArticleDOI
Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
TL;DR: This review focuses on the current understanding of the mechanisms underlying intranasal delivery to the central nervous system involving the olfactory and trigeminal nerves, the vasculature, the cerebrospinal fluid, and the lymphatic system.
References
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Book
An Introduction to Fluid Dynamics
TL;DR: The dynamique des : fluides Reference Record created on 2005-11-18 is updated on 2016-08-08 and shows improvements in the quality of the data over the past decade.
Journal ArticleDOI
An Introduction to Fluid Dynamics. By G. K. Batchelor. Pp. 615. 75s. (Cambridge.)
TL;DR: In this paper, the Navier-Stokes equation is derived for an inviscid fluid, and a finite difference method is proposed to solve the Euler's equations for a fluid flow in 3D space.
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“Gray's Anatomy”
TL;DR: The comparison, made by Dr. W. D. Jeans in your last issue*, of Gray's Anatomy with the latest revision of its American offspring is an interesting exercise; but his conclusion that the original is a ‘better buy’, though pleasing to the producers of the “British” Gray’s Anatomy, is based upon the false premise that a second version is necessary.
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Method for the calculation of velocity, rate of flow and viscous drag in arteries when the pressure gradient is known
TL;DR: The experiments of McDonald and his co-workers have shown that in the larger arteries of the rabbit and the dog there is a reversal of the flow, and the simple mathematical treatment has strong similarities with the theory of the distribution of alternating current in a conductor of finite size.
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Peristaltic pumping with long wavelengths at low Reynolds number
TL;DR: In this article, the authors investigated the effect of peristaltic wave propagation on the flow of fluid in a tube and showed that the theoretical pressure rise per wavelength decreases linearly with increasing time-mean flow and that the percentage of reflux flow can be very high.