Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review
TLDR
Improving adherence in schizophrenia may have a considerable positive impact on patients and society by focusing on the identified multitude of factors driving nonadherence, including lack of insight, medication beliefs and substance abuse.Abstract:
Background:Nonadherence to medication is a recognized problem and may be the most challenging aspect of treatment.Methods:We performed a systematic review of factors that influence adherence and the consequences of nonadherence to the patient, healthcare system and society, in patients with schizophrenia. Particular attention was given to the effect of nonadherence on hospitalization rates, as a key driver of increased costs of care. A qualitative systematic literature review was conducted using a broad search strategy using disease and adherence terms. Due to the large number of abstracts identified, article selection was based on studies with larger sample sizes published after 2001. Thirty-seven full papers were included: 15 studies on drivers and 22 on consequences, of which 12 assessed the link between nonadherence and hospitalization.Results:Key drivers of nonadherence included lack of insight, medication beliefs and substance abuse. Key consequences of nonadherence included greater risk of relapse,...read more
Citations
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Journal ArticleDOI
Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: a systematic review and meta-analysis
Agumasie Semahegn,Agumasie Semahegn,Kwasi Torpey,Adom Manu,Nega Assefa,Gezahegn Tesfaye,Augustine Ankomah +6 more
TL;DR: Individual patient’s behaviors, lack of social support, clinical or treatment and illness-related, and health system factors influenced psychotropic medication non-adherence, which was influenced by various factors operating at different levels.
Journal ArticleDOI
Efficacy and Safety of Paliperidone Palmitate 3-Month Formulation for Patients with Schizophrenia: A Randomized, Multicenter, Double-Blind, Noninferiority Study
Adam Savitz,Haiyan Xu,Srihari Gopal,Isaac Nuamah,Paulien Ravenstijn,Adam Janik,Alain Schotte,David Hough,W. Wolfgang Fleischhacker +8 more
TL;DR: PP3M was noninferior to PP1M: relapse rates were similar in both groups and increased weight was the most common treatment-emergent adverse event (double-blind phase; 21% each).
Journal ArticleDOI
Clinical and economic impact of non-adherence to antidepressants in major depressive disorder: A systematic review
Siew Ching Ho,Huey Yi Chong,Nathorn Chaiyakunapruk,Balamurugan Tangiisuran,Sabrina Anne Jacob,Sabrina Anne Jacob +5 more
TL;DR: There is a strong association between non-adherence to antidepressants and a worsening of patients' clinical and economic outcomes and cost-effective interventions should be directed to this group of patients to improve medication adherence.
Journal ArticleDOI
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.
Douglas M. Ruderfer,Alexander W. Charney,Ben Readhead,Brian A. Kidd,Anna K. Kähler,Paul J. Kenny,Michael J. Keiser,Jennifer L. Moran,Christina M. Hultman,Stuart A. Scott,Patrick F. Sullivan,Shaun Purcell,Joel T. Dudley,Pamela Sklar +13 more
TL;DR: The results support genetic overlap between schizophrenia pathogenesis and antipsychotic mechanism of action and provide evidence of a role for rare functional variants in antipsychotics treatment response, pointing to a subset of patients where their genetic information could inform treatment.
Journal ArticleDOI
Does relapse contribute to treatment resistance? Antipsychotic response in first- vs. second-episode schizophrenia.
Hiroyoshi Takeuchi,Hiroyoshi Takeuchi,Cynthia Siu,Gary Remington,Gagan Fervaha,Gagan Fervaha,Robert B. Zipursky,Robert B. Zipursky,George Foussias,Ofer Agid,Ofer Agid +10 more
TL;DR: It is suggested that antipsychotic treatment response is reduced or delayed in the face of relapse following effective treatment of the first episode of schizophrenia.
References
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Journal ArticleDOI
Measurement-based psychiatry: definitions of response, remission, stability, and relapse in schizophrenia.
Stefan Leucht,John M. Kane +1 more
Journal ArticleDOI
A Prospective Study of Factors Influencing Adherence to a Continuous Neuroleptic Treatment Program in Schizophrenia Patients During 2 Years
Michael Linden,Frank Godemann,Wolfgang Gaebel,Wolfgang Köpke,Peter Müller,Franz Müller-Spahn,Adolf Pietzcker,Jürger Tegeler +7 more
TL;DR: Factors suspected to predict dropout from continuous neuroleptic treatment in a 2-year prospective study involving 122 outpatients with a DSM-III-R diagnosis of schizophrenia concluded that the prediction of dropouts is insufficient and remains largely an unsolved problem.
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Monitoring and managing weight gain in the mentally ill.
Journal ArticleDOI
Dosing frequency and adherence in chronic psychiatric disease: systematic review and meta-analysis
TL;DR: Differences in study design and adherence measures used across the studies were too large to allow pooling of all results, but there was a consistent trend of better adherence with less frequent dosing.
Journal ArticleDOI
Subjective side effects of antipsychotics and medication adherence in people with schizophrenia.
TL;DR: Great attention needs to be paid to age- and gender-specific side effects and to monitoring side effects in people prescribed atypical medication antipsychotics.
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