Journal ArticleDOI
Medicinal importance of fungal β-(1→3), (1→6)-glucans
Jiezhong Chen,Robert J. Seviour +1 more
TLDR
Non-cellulosic β-glucans are now recognized as potent immunological activators, and some are used clinically in China and Japan, where they are effective in treating diseases like cancer, a range of microbial infections, hypercholesterolaemia, and diabetes.About:
This article is published in Fungal Biology.The article was published on 2007-06-01. It has received 442 citations till now. The article focuses on the topics: Receptor & Lactosylceramide.read more
Citations
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The effects of β-glucan on human immune and cancer cells
TL;DR: No good quality clinical trial data is available on assessing the effectiveness of purified β-glucans among cancer patients, so future effort should direct at performing well-designed clinical trials to verify the actual clinical efficacy of β- Glucans or β- glucans containing compounds.
Journal ArticleDOI
Edible Mushrooms: Improving Human Health and Promoting Quality Life
TL;DR: Mushrooms act as antibacterial, immune system enhancer and cholesterol lowering agents, and are important sources of bioactive compounds; additionally, some mushroom extracts are used to promote human health and are found as dietary supplements.
Journal ArticleDOI
Interactions of fungal pathogens with phagocytes
TL;DR: How fungi, particularly Candida albicans, interact with phagocytic cells is described and the many factors that contribute to fungal immune evasion and prevent host elimination of these pathogenic microorganisms are discussed.
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Current findings, future trends, and unsolved problems in studies of medicinal mushrooms
TL;DR: Several of the mushroom polysaccharide compounds have proceeded through phases I, II, and III clinical trials and are used extensively and successfully in Asia to treat various cancers and other diseases.
Journal ArticleDOI
Antitumor activity of mushroom polysaccharides: a review
TL;DR: This review aims to integrate the information regarding nutritional, chemical and biological aspects of polysaccharides in mushrooms, which will possibly be employed to elucidate the correlation between their structural features and biological functions.
References
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Journal ArticleDOI
Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
Journal ArticleDOI
Interleukin-12 and the regulation of innate resistance and adaptive immunity
TL;DR: The understanding of the relative roles of IL-12 and other factors in TH1-type maturation of both CD4+ and CD8+ T cells is discussed here, including the participation in this process ofIL-23 and IL-27, two recently discovered members of the new family of heterodimeric cytokines.
Journal ArticleDOI
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
Adrian Ozinsky,David M. Underhill,Jason D. Fontenot,Adeline M. Hajjar,Kelly D. Smith,Christopher B. Wilson,Lea Schroeder,Alan Aderem +7 more
TL;DR: The data suggest that TLRs sample the contents of the phagosome independent of the nature of the contents, and can establish a combinatorial repertoire to discriminate among the large number of pathogen-associated molecular patterns found in nature.
Journal ArticleDOI
The biology of cachectin/TNF--a primary mediator of the host response
Bruce Beutler,Anthony Cerami +1 more
TL;DR: A limited number of cytokines are capable of orches trating disease states that scarcely resemble one another; among them, endotoxic shock, graft-vs-host disease, cerebral malaria, and cancer cachexia.
Journal ArticleDOI
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
TL;DR: This report examines how dectin-1, a lectin family receptor for β-glucans, collaborates with TLRs in recognizing microbes and demonstrates that collaborative recognition of distinct microbial components by different classes of innate immune receptors is crucial in orchestrating inflammatory responses.
Related Papers (5)
(1→3)-β-d-Glucans as biological response modifiers: a review of structure-functional activity relationships
John A. Bohn,James N. BeMiller +1 more