Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases
Fang Luo,Aaron F. Sandhu,Wiramon Rungratanawanich,George E. Williams,Mohammed Akbar,Shuanhu Zhou,Byoung Joon Song,Xin Wang +7 more
TLDR
The neuroprotective role of melatonin against various N DDs via regulating autophagy is discussed, which could be a new field for future translational research and clinical studies to discover preventive or therapeutic agents for many NDDs.Citations
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Autophagy and neurodegeneration
TL;DR: In this paper, the authors consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology and discuss some of the signaling pathways that may be amenable to therapeutic targeting for these goals.
Journal ArticleDOI
Is Melatonin the Cornucopia of the 21st Century
Nadia Ferlazzo,Giulia Andolina,Attilio Cannata,Maria Giovanna Costanzo,Valentina Rizzo,Monica Currò,Riccardo Ientile,Daniela Caccamo +7 more
TL;DR: The efficacy, safety and side effects of melatonin supplementation in treating oxidative stress- and/or inflammation-related disorders, such as obesity, cardiovascular diseases, immune disorders, infectious diseases, cancer, neurodegenerative diseases, as well as osteoporosis and infertility are reviewed.
Role of sleep deprivation in immune-related disease risk and outcomes.
Sergio Garbarino,Paola Lanteri,Nicola Luigi Bragazzi,Nicola Magnavita,Nicola Magnavita,Egeria Scoditti +5 more
TL;DR: In this article, the authors reviewed recent advancements on the immune responses to sleep deprivation as evidenced by experimental and epidemiological studies, the pathophysiology, and the role for the sleep deprivation-induced immune changes in increasing the risk for chronic diseases.
Journal ArticleDOI
Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis
Jian Qiong Yang,Sha-Sha Hu,Yang-Yang Bian,Jiang-Ling Yao,Dong Ya Wang,Xiaoqian Liu,Zheng-Dong Guo,Siyuan Zhang,Lei Peng +8 more
TL;DR: The pathogenesis of OA in relation to different types of cytokine-triggered cell death and the molecular mechanisms of action between different cell death types and OA are reviewed.
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Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease.
Jesús Burillo,Patricia Marqués,Beatriz Jiménez,Carlos González-Blanco,Manuel Benito,Carlos Guillén +5 more
TL;DR: In this article, the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer's disease were analyzed.
References
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Apoptosis: A Review of Programmed Cell Death
TL;DR: The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including morphology, biochemistry, the role of apoptoses in health and disease, detection methods, as well as a discussion of potential alternative forms of apoptotic proteins.
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Autophagy fights disease through cellular self-digestion
TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
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Autophagy: process and function
TL;DR: In this review, the process of autophagy is summarized, and the role of autophileagy is discussed in a process-based manner.