Journal ArticleDOI
Melatonin effects on behavior: possible mediation by the central GABAergic system.
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TLDR
The effects of melatonin in rodent behavior are described, focusing on inhibitory effects (sedation, hypnotic activity, pain perception threshold elevation), and direct effects on circadian rhythmicity (entrainment, resynchronization, alleviation of jet-lag symptoms, phase-shifting).About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 1996-01-01. It has received 203 citations till now. The article focuses on the topics: Light effects on circadian rhythm & Melatonin.read more
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The neurobiology and control of anxious states
TL;DR: The present article focuses in particular upon the multifarious and complex roles of individual modulators, often as a function of the specific receptor type and neuronal substrate involved in their actions; novel targets for the management of anxiety disorders; the influence of neurotransmitters and other agents upon performance in the VCT; data acquired from complementary pharmacological and genetic strategies and, finally, several open questions likely to orientate future experimental- and clinical-research.
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Melatonin—A pleiotropic, orchestrating regulator molecule
Rüdiger Hardeland,Daniel P. Cardinali,Venkatramanujam Srinivasan,D. Warren Spence,Gregory M. Brown,Seithikurippu R. Pandi-Perumal +5 more
TL;DR: Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging.
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Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
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Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.
Seithikurippu R. Pandi-Perumal,Seithikurippu R. Pandi-Perumal,Ahmed S. BaHammam,Gregory M. Brown,Gregory M. Brown,D. Warren Spence,Vijay K. Bharti,Charanjit Kaur,Rüdiger Hardeland,Daniel P. Cardinali +9 more
TL;DR: Melatonin’s efficacy in combating free radical damage in the brain suggests that it can be a valuable therapeutic agent in the treatment of cerebral edema following traumatic brain injury or stroke.
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Melatonin and its analogs in insomnia and depression.
Daniel P. Cardinali,Venkataramanujan Srinivasan,Amnon Brzezinski,Gregory M. Brown,Gregory M. Brown +4 more
TL;DR: Clinical trials employing melatonin doses in the range of 50–100 mg/day are warranted before the relative merits of the melatonin analogs versus melatonin can be settled, in view of the higher binding affinities, longest half‐life and relative higher potencies of the different melatonin agonists.
References
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Exogenous and endogenous components in circadian rhythms.
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Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
TL;DR: The cloning and characterization of a high affinity receptor for melatonin from the sheep and human is reported, likely mediates the reproductive and circadian actions of melatonin in mammals.
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The pineal gland.
TL;DR: It is not yet certain what pbysiobgical~dependontbepineal clock for cues is, but there is evidence at band ~ggest that the pineal participates in sanewayintbequlationoftbegonads,orsexglands.
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Melatonin shifts human circadian rhythms according to a phase-response curve.
TL;DR: The human melatonin PRC provides critical information for using melatonin to treat circadian phase sleep and mood disorders, as well as maladaptation to shift work and transmeridional air travel.