Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular in vitro bioactivity
TLDR
It was proved that the kinetics of drug release improved with increasing magnesium content and the porosity and the specific surface area were found to be responsible for this improvement.Abstract:
The effects of the magnesium doping of binary glass (Si–Ca) on particle texture, on the biomineralization process in simulated body fluid (SBF) as well as on drug loading and release were examined. For this purpose, magnesium-doped binary bioglass nanoparticles (85SiO2–(15 − x)CaO–xMgO, with x = 1, 3, 5 and 10 mol%) were prepared by a base catalysed sol–gel method. N2 adsorption isotherm analysis showed an enhancement in specific surface area as the Mg molar fraction increased. In addition, the FTIR spectra of the samples after soaking in SBF for various periods of time confirmed the presence of new chemical bonds related to the apatite phase, as was also confirmed by SEM observations. XRD patterns of the samples after soaking revealed that the crystallization to form a more stable apatite-like phase was hindered with increasing magnesium content in the glass composition. Furthermore, it was proved that the kinetics of drug release improved with increasing magnesium content. The porosity and the specific surface area were found to be responsible for this improvement.read more
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Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing.
TL;DR: This review focuses on skin structure, the dynamic process of wound healing in injured skin, and existing wound care approaches and the active role of bioactive glasses in wound repair and regeneration.
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Multi-functional silica-based mesoporous materials for simultaneous delivery of biologically active ions and therapeutic biomolecules.
TL;DR: In this paper, a review of mesoporous bioactive glasses (MBGs) for co-delivery of ions and drugs with osteogenesis/cementogenesis, angiogenesis, antibacterial and anticancer properties is presented.
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Current advances concerning the most cited metal ions doped bioceramics and silicate-based bioactive glasses for bone tissue engineering
Vanessa Modelski Schatkoski,Thaís Larissa do Amaral Montanheiro,Beatriz Rossi Canuto de Menezes,Raissa Monteiro Pereira,Karla Faquine Rodrigues,Renata Guimarães Ribas,Diego Morais da Silva,Gilmar Patrocínio Thim +7 more
TL;DR: This review aims to summarize the effect of selected metal ion dopants into bioceramics and silicate-based BGs in bone tissue engineering, and new applications for doped biocers and BGs are highlighted, including cancer treatment and drug delivery.
Journal ArticleDOI
Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli-Responsive, Toxicity, Immunogenicity, and Clinical Translation
Esmaeel Sharifi,Ashkan Bigham,Satar Yousefiasl,Maria Trovato,Matineh Ghomi,Matineh Ghomi,Yasaman Esmaeili,Pouria Samadi,Ali Zarrabi,Milad Ashrafizadeh,Shokrollah Sharifi,Rossella Sartorius,Farnaz Dabbagh Moghaddam,Aziz Maleki,Hao Song,Tarun Agarwal,Tapas K. Maiti,Nasser Nikfarjam,Colin Burvill,Virgilio Mattoli,Maria Grazia Raucci,Kai Zheng,Aldo R. Boccaccini,Luigi Ambrosio,Pooyan Makvandi +24 more
TL;DR: The mesoporous bioactive glasses (MBGs) have been widely used in cancer diagnosis and therapy as discussed by the authors. But they have not yet met their potential in tumor treatment and imaging in practice, although MBGs have shown promising capabilities as promising systems for cancer imaging and therapy.
Journal ArticleDOI
Enhanced mechanical and biocompatible properties of strontium ions doped mesoporous bioactive glass
S. Amudha,J. Ramana Ramya,J. Ramana Ramya,K. Thanigai Arul,A. Deepika,P. Sathiamurthi,B. Mohana,K. Asokan,Chung-Li Dong,S. Narayana Kalkura +9 more
TL;DR: Very low (≤0.2%) strontium ion doped mesoporous (45S5) bioactive glasses (BG) were synthesized by sol-gel technique and calcination without using polymers (porogens), mould or other additives as mentioned in this paper.
References
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