Methylglyoxal Enhances Cisplatin-induced Cytotoxicity by Activating Protein Kinase Cδ
TLDR
MGO synergistically enhances cisplatin-induced apoptosis through activation of PKCδ and that PKC δ is critical to both cell death and cell survival pathways.About:
This article is published in Journal of Biological Chemistry.The article was published on 2002-01-25 and is currently open access. It has received 73 citations till now. The article focuses on the topics: Rottlerin & Cisplatin.read more
Citations
More filters
Journal ArticleDOI
Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.
Takashi Tsuruo,Mikihiko Naito,Akihiro Tomida,Naoya Fujita,Tetsuo Mashima,Hiroshi Sakamoto,Hiroshi Sakamoto,Naomi Haga +7 more
TL;DR: In this article, a review on molecular cancer therapeutics, including molecular mechanisms and therapeutic approaches, is presented, focusing on the areas of drug resistance, apoptosis and apoptosis resistance, and survival-signaling.
Journal Article
Controlling Tumor Growth by Modulating Endogenous Production of Reactive Oxygen Species
Alexis Laurent,Carole Nicco,Christiane Chéreau,Claire Goulvestre,Jérôme Alexandre,Arnaud Alves,Eva Lévy,François Goldwasser,Yves Panis,Olivier Soubrane,Bernard Weill,Frédéric Batteux +11 more
TL;DR: In conclusion, antioxidant molecules may have opposite effects on tumor growth as SOD mimics can act in synergy with cytotoxic drugs to treat colon and liver cancers and reactive oxygen species can promote normal cellular proliferation and carcinogenesis.
Journal ArticleDOI
Regulation of cell apoptosis by protein kinase c δ
Chaya Brodie,Peter M. Blumberg +1 more
TL;DR: In this paper, the authors present a review of the PKCδ cascades and its role in cell apoptosis, including the role of protein phosphorylation on distinct tyrosine residues and its association with specific apoptotic related proteins.
Journal ArticleDOI
Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease
TL;DR: It is appreciated that glyoxalase 1 protects against dicarbonyl modifications of the proteome, genome and lipome and represents part of the enzymatic defence against glycation.
Book ChapterDOI
Cisplatin-Associated Nephrotoxicity and Pathological Events
TL;DR: Stress responses and heat shock proteins generated following cisplatin treatment are actively involved in the initiation and progression of these events.
References
More filters
Journal ArticleDOI
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.
Diabetes Control,David M. Nathan,Saul M. Genuth,John M. Lachin,Patricia A. Cleary,O Crofford,Matthew M. Davis,Larry Rand,Carolyn Siebert +8 more
TL;DR: Intensive therapy effectively delays the onset and slows the progression of diabetic retinopathy, nephropathy, and neuropathy in patients with IDDM.
Journal ArticleDOI
p53, the Cellular Gatekeeper for Growth and Division
TL;DR: The author regrets the lack of citations for many important observations mentioned in the text, but their omission is made necessary by restrictions in the preparation of review manuscripts.
Journal ArticleDOI
The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
Journal ArticleDOI
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
TL;DR: It is reported here that 2-vinylpyridine is a much better reagent for the derivitization of glutathione, and it is demonstrated that the total glutATHione concentration in mouse plasma is substantially higher than generally reported and that glutathion disulfide constitutes less than 30% of the totalglutathione present.
Journal ArticleDOI
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
Donald W. Nicholson,Ambereen Ali,Nancy A. Thornberry,John P. Vaillancourt,C K Ding,Michel Gallant,Yves Gareau,Patrick R. Griffin,Marc Labelle,Yuri Lazebnik +9 more
TL;DR: A potent peptide aldehyde inhibitor has been developed and shown to prevent apoptotic events in vitro, suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death.