Military-related traumatic brain injury and neurodegeneration
Ann C. McKee,Meghan E. Robinson +1 more
TLDR
Early changes of chronic traumatic encephalopathy are found in four young veterans of the Iraq and Afghanistan conflict who were exposed to explosive blast and in another young veteran who was repetitively concussed.Citations
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Journal ArticleDOI
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
Ann C. McKee,Nigel J. Cairns,Dennis W. Dickson,Rebecca D. Folkerth,C. Dirk Keene,Irene Litvan,Daniel P. Perl,Thor D. Stein,Jean Paul G. Vonsattel,William Stewart,Yorghos Tripodis,John F. Crary,Kevin F. Bieniek,Kristen Dams-O'Connor,Victor E. Alvarez,Wayne A. Gordon +15 more
TL;DR: Preliminary neuropathological criteria were used by 7 neuropathologists to blindly evaluate 25 cases of various tauopathies, including CTE, Alzheimer’s disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy, and parkinsonism dementia complex of Guam to pave the way towards future clinical and mechanistic studies.
Journal ArticleDOI
Functionally-detected cognitive impairment in high school football players without clinically-diagnosed concussion
Thomas M. Talavage,Eric A. Nauman,Evan L. Breedlove,Umit Yoruk,Anne E. Dye,Katherine E. Morigaki,Henry Feuer,Larry J. Leverenz +7 more
TL;DR: Examination of neurological performance and health in the presence of head collision events in high school football players found a previously undiscovered third category of players, who exhibited no clinically-observed symptoms associated with concussion, but who demonstrated measurable neurocognitive and neurophysiological impairments.
Book ChapterDOI
The neuropathology of traumatic brain injury
Ann C. McKee,Daniel H. Daneshvar +1 more
TL;DR: Clinically, chronic traumatic encephalopathy is associated with behavioral changes, executive dysfunction, memory loss, and cognitive impairments that begin insidiously and progress slowly over decades, and may be associated with other neurodegenerative disorders, including Alzheimer's disease, Lewy body disease, and motor neuron disease.
Journal ArticleDOI
The neuropathology of chronic traumatic encephalopathy
TL;DR: It is critical to identify the genetic risk factors for CTE as well as to understand how other variables, such as stress, age at exposure, gender, substance abuse and other exposures, contribute to the development of CTE.
Journal ArticleDOI
Beta-amyloid deposition in chronic traumatic encephalopathy
Thor D. Stein,Thor D. Stein,Thor D. Stein,Philip H. Montenigro,Victor E. Alvarez,Weiming Xia,John F. Crary,Yorghos Tripodis,Daniel H. Daneshvar,Jesse Mez,Todd M. Solomon,Gaoyuan Meng,Caroline A. Kubilus,Kerry Cormier,Steven Meng,Katharine J. Babcock,Patrick T. Kiernan,Lauren Murphy,Christopher J. Nowinski,Brett Martin,Diane Dixon,Robert S. Stern,Robert C. Cantu,Robert C. Cantu,Neil W. Kowall,Neil W. Kowall,Ann C. McKee,Ann C. McKee,Ann C. McKee +28 more
TL;DR: The findings suggest that A β deposition is altered and accelerated in a cohort of CTE subjects compared to normal aging and that Aβ is associated with both pathological and clinical progression of Cte independent of age.
References
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Journal ArticleDOI
Mild Traumatic Brain Injury in U.S. Soldiers Returning from Iraq
Charles W. Hoge,Dennis McGurk,Jeffrey L. Thomas,Anthony L. Cox,Charles C. Engel,Carl A. Castro +5 more
TL;DR: Mildtraumatic brain injury occurring among soldiers deployed in Iraq is strongly associated with PTSD and physical health problems 3 to 4 months after the soldiers return home, and after adjustment for PTSD and depression, mild traumatic brain injury was no longer significantly associated with these physical health outcomes or symptoms, except for headache.
Journal ArticleDOI
Traumatic brain injury.
TL;DR: Quantification of cerebral perfusion by monitoring of intracranial pressure and treatment of cerebral hypoperfusion decrease secondary injury and an organised trauma system that allows rapid resuscitation and transport directly to an experienced trauma centre significantly lowers mortality and morbidity.
Journal ArticleDOI
Consensus statement on Concussion in Sport - The 4th International Conference on Concussion in Sport held in Zurich, November 2012
Paul McCrory,Willem H. Meeuwisse,Mark Aubry,Bob Cantu,Jiří Dvořák,Ruben J. Echemendia,Lars Engebretsen,Lars Engebretsen,Karen M. Johnston,Jeff Kutcher,Martin Raftery,Allen K. Sills,Brian W. Benson,Gavin A Davis,Richard G. Ellenbogen,Kevin M. Guskiewicz,Stanley A. Herring,Grant L. Iverson,Barry D. Jordan,Barry D. Jordan,James Kissick,Michael McCrea,Andrew S. McIntosh,Andrew S. McIntosh,David Maddocks,Michael Makdissi,Michael Makdissi,Laura Purcell,Margot Putukian,Margot Putukian,Kathryn J Schneider,Charles H. Tator,Michael Turner +32 more
TL;DR: The 4th International Conference on Concussion in Sport held in Zurich, November 2012 was attended by Paul McCrory, Willem H Meeuwisse, Mark Aubry, Jiří Dvořák, Ruben J Echemendia, Lars Engebretsen, Karen Johnston, Jeffrey S Kutcher, Martin Raftery, Allen Sills and Kathryn Schneider.
Journal ArticleDOI
Consensus statement on concussion in sport
Paul McCrory,Willem H. Meeuwisse,Mark Aubry,Bob Cantu,Jiří Dvořák,Ruben J. Echemendia,Lars Engebretsen,Karen M. Johnston,Jeffrey S. Kutcher,Martin Raftery,Allen Sills,Brian W. Benson,Gavin A Davis,Richard G. Ellenbogen,Kevin M. Guskiewicz,Stanley A. Herring,Grant L. Iverson,Barry D. Jordan,James Kissick,Michael McCrea,Andrew S. McIntosh,David Maddocks,Michael Makdissi,Laura Purcell,Margot Putukian,Kathryn J Schneider,Charles H. Tator,Michael Turner +27 more
TL;DR: This paper is a revision and update of the recommendations developed following the 1st (Vienna 2001), 2nd (Prague 2004) and 3rd (Zurich 2008) International Consensus Conferences on Concussions in Sport and is based on the deliberations at the 4th International Conference on Concussion in Sport held in Zurich, November 2012.
Journal ArticleDOI
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
Ann C. McKee,Robert C. Cantu,Christopher J. Nowinski,E. Tessa Hedley-Whyte,Brandon E. Gavett,Andrew E. Budson,Veronica Santini,H. J. Lee,Caroline A. Kubilus,Robert S. Stern +9 more
TL;DR: This work reviews 48 cases of neuropathologically verified CTE recorded in the literature and document the detailed findings of CTE in 3 professionalathletes, 1 football player and 2 boxers.
Related Papers (5)
The spectrum of disease in chronic traumatic encephalopathy
Ann C. McKee,Thor D. Stein,Thor D. Stein,Christopher J. Nowinski,Robert S. Stern,Daniel H. Daneshvar,Victor E. Alvarez,H. J. Lee,Garth F. Hall,Sydney M. Wojtowicz,Sydney M. Wojtowicz,Christine M. Baugh,David O. Riley,Caroline A. Kubilus,Kerry Cormier,Matthew A. Jacobs,Brett Martin,Carmela R. Abraham,Tsuneya Ikezu,Robert Ross Reichard,Benjamin Wolozin,Andrew E. Budson,Andrew E. Budson,Lee E. Goldstein,Neil W. Kowall,Robert C. Cantu +25 more
Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.
Lee E. Goldstein,Andrew M. Fisher,Chad A. Tagge,Xiao-Lei Zhang,Libor Velíšek,John A. Sullivan,Chirag Upreti,Jonathan M. Kracht,Maria Ericsson,Mark W. Wojnarowicz,Cezar Goletiani,Giorgi Maglakelidze,Noel Casey,Juliet A. Moncaster,Olga Minaeva,Robert D. Moir,Christopher J. Nowinski,Robert S. Stern,Robert C. Cantu,Robert C. Cantu,James Geiling,Jan Krzysztof Blusztajn,Benjamin Wolozin,Tsuneya Ikezu,Thor D. Stein,Thor D. Stein,Andrew E. Budson,Andrew E. Budson,Neil W. Kowall,Neil W. Kowall,David Chargin,Andre Sharon,Sudad Saman,Garth F. Hall,William C. Moss,Robin O. Cleveland,Rudolph E. Tanzi,Patric K. Stanton,Ann C. McKee,Ann C. McKee +39 more