Molecular signaling in temporomandibular joint osteoarthritis
Reads0
Chats0
TLDR
This review article summarized current findings of signaling pathways involved in TMJ OA, including Wnt/β-catenin, TGF-β and BMP, Indian Hedgehog, FGF, NF-κB, and Notch pathways, to better understand the pathological mechanisms of TMj OA and define the molecular targets for TM J OA treatment.Abstract:
Objective Temporomandibular joint (TMJ) osteoarthritis (OA) is a type of TMJ disorders with clinical symptoms of pain, movement limitation, cartilage degeneration and joint dysfunction. This review article is aiming to summarize recent findings on signaling pathways involved in TMJ OA development and progression. Methods Most recent findings in TMJ OA studies have been reviewed and cited. Results TMJ OA is caused by inflammation, abnormal mechanical loading and genetic abnormalities. The molecular mechanisms related to TMJ OA have been determined using different genetic mouse models. Recent studies demonstrated that several signaling pathways are involved in TMJ OA pathology, including Wnt/β-catenin, TGF-β and BMP, Indian Hedgehog, FGF, NF-κB, and Notch pathways, which are summarized in this review article. Alterations of these signaling pathways lead to the pathological changes in TMJ tissues, affecting cartilage matrix degradation, catabolic metabolism and chondrocyte apoptosis. Conclusion Multiple signaling pathways were involved in the pathological process of TMJ OA. New therapeutic strategies, such as stem cell application, gene editing and other techniques may be utilized for TMJ OA treatment. The translational potential of this article TMJ OA is a most important subtype of TMJ disorders and may lead to substantial joint pain, dysfunction, dental malocclusion, and reduced health-related quality of life. This review article summarized current findings of signaling pathways involved in TMJ OA, including Wnt/β-catenin, TGF-β and BMP, Indian Hedgehog, FGF, NF-κB, and Notch pathways, to better understand the pathological mechanisms of TMJ OA and define the molecular targets for TMJ OA treatment.read more
Citations
More filters
Journal ArticleDOI
Current understanding of osteoarthritis pathogenesis and relevant new approaches
Liping Tong,Huan Yu,Xingyun Huang,Jie Shen,Guozhi Xiao,Li Chen,Huaiyu Wang,Lianping Xing,Di Chen +8 more
TL;DR: In this article , a review of epigenetic regulation of OA, with a particular focus on DNA methylation, histone modification, and microRNA regulation, is presented, followed by a summary of several key mediators in OA-associated pain.
Journal ArticleDOI
Osteoarthritis Pain
TL;DR:
Journal ArticleDOI
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Qing Yao,Xiaohao Wu,Chu Tao,Weiyuan Gong,Mingju Chen,Minghao Qu,Yiming Zhong,Tailin He,Sheng Chen,Guozhi Xiao +9 more
TL;DR: In this paper , the role and regulation of pathological signaling pathways, such as Wnt/β-catenin, NF-κB, focal adhesion, HIFs, TGFβ/ΒΜP and FGF signalling pathways, and key regulators AMPK, mTOR, and RUNX2 in the onset and development of OA are discussed in detail.
Journal ArticleDOI
Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice
Yumei Lai,Wei Zheng,Minghao Qu,Christopher C. Xiao,Sheng Chen,Qing Yao,Weiyuan Gong,Chu Tao,Qinnan Yan,Peijun Zhang,Xiaohao Wu,Guozhi Xiao +11 more
TL;DR: In this paper , a key focal adhesion protein, Kindlin-2, is strongly detected in cells of mandibular condylar cartilage in mice and it is shown that Kindlin2 loss significantly downregulates the expression of aggrecan, Col2a1 and Proteoglycan 4 (Prg4), all anabolic extracellular matrix proteins, and promotes catabolic metabolism in temporomandibular joint (TMJ) cartilage.
References
More filters
Journal ArticleDOI
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TL;DR: This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.
Journal ArticleDOI
A new member of the frizzled family from Drosophila functions as a Wingless receptor.
Purnima Bhanot,Marcel Brink,Cindy Harryman Samos,Jen Chih Hsieh,Yanshu Wang,Jennifer P. Macke,Deborah J. Andrew,Jeremy Nathans,Roel Nusse +8 more
TL;DR: It is shown that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein, implying that Frizzled proteins are receptors for the Wnt signalling molecules.
Journal ArticleDOI
The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.
Journal ArticleDOI
30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology
TL;DR: The NF-κB was discovered 30 years ago as a rapidly inducible transcription factor and has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system as mentioned in this paper.
Journal ArticleDOI
PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth
Beate Lanske,Andrew C. Karaplis,Kaechong Lee,Arne Luz,Andrea Vortkamp,Alison E. Pirro,Marcel Karperien,L. H. K. Defize,Chrystal Ho,Richard C. Mulligan,Abdul-Badi Abou-Samra,Harald Jüppner,Gino V. Segre,Henry M. Kronenberg +13 more
TL;DR: The results suggest that the PTH/P THrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation.
Related Papers (5)
Wnt/β-catenin Signaling in Osteoarthritis and in Other Forms of Arthritis
Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB.
Taku Saito,Sakae Tanaka +1 more