Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
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TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
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Journal ArticleDOI
Pathophysiology of Depressive Illness: Review of the Literature and Case Example
TL;DR: A case example illustrates the complicated interaction of psychological and physiological variables in the genesis of depression and the utility of new laboratory tests to establish diagnosis and determine appropriate therapy.
Journal ArticleDOI
Comparison of Plasma Levels of Tryptophan Metabolites between Healthy People and Patients of Bipolar Depression at Various Age and Gender
TL;DR: Plasma levels of 5-HT are higher in patients of BDII than those of HC, which may suggest that use of drugs inhibiting the 5-HIAA transportation and lower transporter biding may increase plasma levels of5-HT in Patients of BD.
Dissertation
PET studies of the serotonin transporter in the human brain
TL;DR: C-labelled MADAM was shown to be a suitable radioligand for quantitative studies of 5-HTT in the living human brain, and can readily be applied for clinical studies also on small regions such as the raphe nuclei, although pooling of data may be required for bilateral regions to improve accuracy.
Book ChapterDOI
Review of Imipramine Binding in Platelets from Psychiatric Patients: Its Relevance to the Biology of Suicide
D. Marazziti,G. M. Pacifici +1 more
TL;DR: In this paper, the authors studied the relationship between suicidal behavior and the concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in the brain of suicides.
References
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Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
A comprehensive psychopathological rating scale.
TL;DR: An interdisciplinary group of 15 psychiatrists, psychologists and clinical pharmacologists was formed under the auspices of the Swedish Medical Research Council to study the problem of evaluating change in psychiatric disorders with treatment and decided to construct a new scale covering psychopathological variables likely to be changed by treatment.