Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
Reads0
Chats0
TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
More filters
Journal ArticleDOI
Evidence-based pharmacotherapy for personality disorders
TL;DR: Most available evidence supports use of medication in reducing impulsivity and aggression, characteristic of borderline and antisocial psychopathology, andirect evidence is provided for psychopharmacological reduction of social anxiety central to avoidant personality disorder.
Journal ArticleDOI
Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients
Wade H. Berrettini,John I. Nurnberger,Mika Scheinin,Timo Seppälä,Markku Linnoila,William Narrow,Susan Simmons-Alling,Elliot S. Gershon +7 more
TL;DR: No evidence of a trait marker for manic-depressive illness among CSF monoamines and their metabolites is found and dopaminergic and serotonergic metabolites were highly correlated in the CSF of all three groups.
Journal ArticleDOI
CSF monoamine metabolites in schizophrenic patients.
TL;DR: Positive correlations were found between the level of 5‐HIAA and the items: hallucinatory behaviour, grandiosity, and tension as rated on the Brief Psychiatric Rating Scale.
Journal ArticleDOI
CSF monoamine metabolites in chronic schizophrenic patients who attempt suicide.
Alec Roy,Philip T. Ninan,Anne Mazonson,David Pickar,D. Van Kammen,Markku Linnoila,Sharmishtha Paul +6 more
TL;DR: Significantly more of the suicide attempters had a previous major depressive episode, had received a course of ECT, and had significantly more psychiatric admissions than those who had never attempted suicide.
Journal ArticleDOI
The case for biology in the aetiology of anorexia nervosa
Janet Treasure,Iain C. Campbell +1 more
TL;DR: An important deficit in both the familial and cultural models is the failure to account for individual susceptibility, which leads in some to the development of anorexia nervosa in the context of general environmental hazards.
References
More filters
Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
A comprehensive psychopathological rating scale.
TL;DR: An interdisciplinary group of 15 psychiatrists, psychologists and clinical pharmacologists was formed under the auspices of the Swedish Medical Research Council to study the problem of evaluating change in psychiatric disorders with treatment and decided to construct a new scale covering psychopathological variables likely to be changed by treatment.