Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
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TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
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The sociopath: Cheater or warrior hawk?
TL;DR: It is suggested that violent competition in ancestral bands – and not “cheating” in the “game” of cooperation – was the primary evolutionary precursor of sociopathy.
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CYP2D6, serotonin, and suicide-a relationship?
TL;DR: Data seem to indicate that serotonergic mechanisms are involved in etiology of suicidal behavior, and an alternative explanation to the overrepresentation of CTYP2D6 gene duplication among the suicide cases was touched on.
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CSF monoamine metabolites in chronic pain
TL;DR: Chronic pain states are associated with elevation of CSF 5‐HIAA in female patients and depression abolishes a positive correlation between 5‐ HIAA and HVA, and monoamine metabolites and beta‐endorphin.
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Behavioural neuroscience: A gene for impulsivity
TL;DR: Exon sequencing focusing on 14 serotonin and dopamine-related genes in severely impulsive Finnish criminal offenders reveals linkage to a mutation in the stop codon HTR2B, which encodes the 5HT2B serotonin receptor, which was not previously known to influence behaviour.
Journal ArticleDOI
Psychological and genetic risk factors associated with suicidal behavior in Korean patients with mood disorders.
Hee Yeon Choi,Ga Eun Kim,Ga Eun Kim,Kyoung Ae Kong,Yu Jin Lee,Weon Jeong Lim,So Hyun Park,Su Hee Ha,Soo In Kim +8 more
TL;DR: Suicidal behavior in Korean patients with mood disorders may be associated with younger age, alcohol consumption, depressive symptoms, poor social support, less social support-seeking coping, and the COMT rs4680 Met/Met genotype.
References
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Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
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Journal ArticleDOI
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