Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
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TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
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Fluoxetine: Adverse Effects and Drug-Drug Interactions
TL;DR: The adverse reactions of fluoxetine include the "serotonin syndrome", cardiovascular complications, extrapyramidal side effects such as akathisia, dyskinesias, and parkinsonian-like syndromes and an apparently increased risk of suicidality.
Journal ArticleDOI
Role of dopamine in non-depressed patients with a history of suicide attempts
TL;DR: In conclusion, dopaminergic disturbances seem to play a role in the biology of inward-directed aggression in non-depressed patients.
Journal ArticleDOI
Two-tier diagnosing in psychiatry.
TL;DR: A functional organization of psychopathology is considered the most appropriate framework for biological research and a plea is made for a two-tier diagnostic system of psychiatric disorders in this article, which comprises the nosological diagnosis, and a detailed depiction of the component psychological dysfunctions.
Journal ArticleDOI
Dopamine D2 receptor gene polymorphisms are associated with suicide attempt in the Japanese population.
Akira Suda,Chiaki Kawanishi,Ikuko Kishida,Ryoko Sato,Tomoki Yamada,Makiko Nakagawa,Hana Hasegawa,Daiji Kato,Taku Furuno,Yoshio Hirayasu +9 more
TL;DR: In this article, the authors examined associations between D2 dopaminergic function and suicidal behavior and found that D2 dopamine function was associated with suicidal behavior in the expression of suicidal behavior.
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Effect of aging on lazabemide binding, monoamine oxidase activity and monoamine metabolites in human frontal cortex.
TL;DR: The present data confirm in a direct manner that the increase in MAO-B activity in aging brain is due to an enhancement of the number of active sites of the enzyme and not through modifications of its kinetic characteristics.
References
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Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
A comprehensive psychopathological rating scale.
TL;DR: An interdisciplinary group of 15 psychiatrists, psychologists and clinical pharmacologists was formed under the auspices of the Swedish Medical Research Council to study the problem of evaluating change in psychiatric disorders with treatment and decided to construct a new scale covering psychopathological variables likely to be changed by treatment.