Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
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TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
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Journal ArticleDOI
HPA axis hyperactivity and attempted suicide in young adult mood disorder inpatients.
Jussi Jokinen,Peter Nordström +1 more
TL;DR: The results add to previous evidence in support of the role of HPA axis hyperactivity and suicidal behaviour and motivate to include HPAaxis axis measures in the assessment of depression in young adults.
Journal ArticleDOI
Comparison of cerebrospinal fluid monoamine metabolite levels in dominant-aggressive and non-aggressive dogs
TL;DR: It is suggested that reduced serotonergic function is associated with aggressive behavior and impaired impulse control in dogs, a finding that is consistent with observations in primates, and suggests that serotonin modulates aggressive behavior throughout mammals.
Journal ArticleDOI
Amine metabolites and neuroendocrine responses related to depression and suicide
Csaba M. Banki,Mihály Arató +1 more
TL;DR: Suicidal patients, and in particular those who used violent methods, tended to have lower 5-HIAA, but not HVA, in their CSF; they also more often had non-suppression of cortisol after dexamethasone, and neither suicide nor postdexamethAsone cortisol levels showed any relation to maximal TSH changes.
Journal ArticleDOI
Clinical neurochemistry of autism and associated disorders.
TL;DR: The fundamental preclinical and clinical studies of serotonin, dopamine, and norepinephrine metabolism related to infantile autism are reviewed, and new studies are suggested, as examples of the productive strategies that will illuminate features of the autistic syndrome in the next decade.
Journal ArticleDOI
Neurotransmitter-neuroendocrine responses to experimentally induced aggression in humans: influence of personality variable.
Gilberto Gerra,Amir Zaimovic,Paola Avanzini,Beatrice Chittolini,Giuliano Giucastro,Rocco Caccavari,Mariella Palladino,D. Maestri,Cesare Monica,Roberto Delsignore,Francesca Brambilla +10 more
TL;DR: Basal Te and stimulated NE, GH and Cort levels were higher in subjects with high-normal than in those with low-normal aggressiveness, suggesting that the functional tonus of the NE system and of theNE-dependent hormonal axes might be a modulator of the behavioral parameter.
References
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Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
A comprehensive psychopathological rating scale.
TL;DR: An interdisciplinary group of 15 psychiatrists, psychologists and clinical pharmacologists was formed under the auspices of the Swedish Medical Research Council to study the problem of evaluating change in psychiatric disorders with treatment and decided to construct a new scale covering psychopathological variables likely to be changed by treatment.