Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
Reads0
Chats0
TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
More filters
Journal ArticleDOI
Disproportionate suicidality in patients with comorbid major depression and alcoholism.
Jack R. Cornelius,Ihsan M. Salloum,Juan E. Mezzich,Marie D. Cornelius,Horacio Fabrega,Joan G. Ehler,Richard F. Ulrich,Michael E. Thase,J. John Mann +8 more
TL;DR: The clinical profile of depressed alcoholics suggests that they suffer an additive or synergistic effect of two separate disorders, resulting in a disproportionately high level of acute suicidality upon initial psychiatric evaluation.
Journal ArticleDOI
Aggressivity, suicide attempts, and depression: Relationship to cerebrospinal fluid monoamine metabolite levels
Giovanni P. A. Placidi,Maria A. Oquendo,Kevin M. Malone,Yung-yu Huang,Steven P. Ellis,J. John Mann +5 more
TL;DR: Lower CSF 5-HIAA concentration was independently associated with severity of lifetime aggressivity and a history of a higher lethality suicide attempt and may be part of the diathesis for these behaviors.
Journal ArticleDOI
Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients
J. John Mann,Kevin M. Malone +1 more
TL;DR: Serotonergic function is lower in depressed patients who have carried out high-lethality suicide attempts resulting in more medical damage, which might explain differences in serotonergic activity among depressed suicide attempters.
Journal ArticleDOI
Lower dopamine transporter binding potential in striatum during depression
Jeffrey H. Meyer,Stephanie Krüger,Alan A. Wilson,Bruce K. Christensen,Verdell S. Goulding,Ayal Schaffer,Candace E. Minifie,Sylvain Houle,Doug Hussey,Sidney H. Kennedy +9 more
TL;DR: There was a strong, highly significant, inverse correlation between striatal DATBP and neuropsychological tests of dopamine-implicated symptoms in patients (i.e. patients with lower DAT BP performed better), and lower Dat BP itself reduces extracellular clearance of dopamine.
Journal ArticleDOI
Assessment of suicide risk.
TL;DR: The problems in assessing suicide risk are explored, and the risks of suicide for patients with major psychiatric disorders and for particular clinical populations, including hospitalised patients and suicide attempters, are examined.
References
More filters
Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
A comprehensive psychopathological rating scale.
TL;DR: An interdisciplinary group of 15 psychiatrists, psychologists and clinical pharmacologists was formed under the auspices of the Swedish Medical Research Council to study the problem of evaluating change in psychiatric disorders with treatment and decided to construct a new scale covering psychopathological variables likely to be changed by treatment.