Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
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TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
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Neuroanatomy of Serotonergic Abnormalities in Suicide
Helene Bach,Victoria Arango +1 more
TL;DR: A large body of work has focused on serotonin (5-HT) deficits in major depressive disorder (MDD) and suicide A great deal has been learned about the anatomy, development, and functional organization of the 5-HT system and the alterations in this system that are present within the suicide brain this article.
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Monoamine neurotransmitters in human aggressiveness and violence: a selective review
Journal ArticleDOI
Relationship of Headaches to Depression
TL;DR: Patients with an increase in depressive headaches were younger, had more somatic complaints, and experienced more hypersomnia than other depressives.
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The Association of Bipolar Spectrum Disorders and Borderline Personality Disorder
TL;DR: Concerning medication treatment, antidepressants are considered effective in BPD, whereas mood stabilizers are the main treatment of choice in BD, and psychotherapeutic methods is still under research for both disorders.
Journal ArticleDOI
The role of the serotonergic system in suicidal behavior.
Marta Sadkowski,Brittany B. Dennis,Robert C Clayden,Wala El-Sheikh,Sumathy Rangarajan,Jane DeJesus,Zainab Samaan +6 more
TL;DR: This review summarizes recent research into ten serotonergic genes related to SB and employs a systematic search strategy and a narrative research methodology to disseminate the current literature investigating the link between SB and serotonin.
References
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Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
A comprehensive psychopathological rating scale.
TL;DR: An interdisciplinary group of 15 psychiatrists, psychologists and clinical pharmacologists was formed under the auspices of the Swedish Medical Research Council to study the problem of evaluating change in psychiatric disorders with treatment and decided to construct a new scale covering psychopathological variables likely to be changed by treatment.