Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
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A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
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Possible clinical applications of serenics and some implications of their preclinical profile for their clinical use in psychiatric disorders.
TL;DR: In this paper, the authors propose a method to solve the problem of "uniformity" and "unweighting" in the literature.Page 7.1.1]
Journal ArticleDOI
Adaptive and nonadaptive explanations of sociopathy
Chris Moore,Michael R. Rose +1 more
TL;DR: It is argued that most human social behavior is not under tight genetic control, but is produced by open-ended calculation of fitness-contingencies.
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Low total cholesterol and low-density lipoprotein associated with aggression and hostility in recent suicide attempters
TL;DR: The findings suggest that low cholesterol is associated with both state and trait aggression in suicide attempters, and low cholesterol was more robustly associated with personality trait items related to interpersonal aggression, as opposed to Items related to irritability or more indirect, non-overt aggression.
Suicide : autopsie psychologique, outil de recherche en prévention
TL;DR: For instance, in France, the number of suicides aboutis is about 11,000 per année as discussed by the authors, which represents approximately 2 % of all suicides in the world, according to the World Health Organization (WHO).
Journal ArticleDOI
Fluoxetine Not Associated With Increased Violence or Aggression in Controlled Clinical Trials
John H. Heiligenstein,Emil F. Coccaro,Janet H. Potvin,Charles M. Beasley,Bruce E. Dornseif,Daniel N. Masica +5 more
TL;DR: Adverse event terms possibly involving physically assaultive acts toward another (antisocial reaction, hostility, and personality disorder, together termed the “aggression cluster”) were reviewed and across all indications, a statistically significantly smaller proportion of fluoxetine-treated patients than placebo- treated patients experienced one or more of the events.
References
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Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
A comprehensive psychopathological rating scale.
TL;DR: An interdisciplinary group of 15 psychiatrists, psychologists and clinical pharmacologists was formed under the auspices of the Swedish Medical Research Council to study the problem of evaluating change in psychiatric disorders with treatment and decided to construct a new scale covering psychopathological variables likely to be changed by treatment.