Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
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TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
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Journal ArticleDOI
Suicidal behavior in depression: Relationship to noradrenergic function
TL;DR: Depressed patients who had or had never attempted suicide and controls on cerebrospinal fluid, plasma, and urinary indices of noradrenergic function suggest that the nor adrenergic system is probably not a major determinant of suicidal behavior in depressed patients.
Journal ArticleDOI
CSF testosterone in 43 male suicide attempters.
TL;DR: Testosterone in cerebrospinal fluid was analysed in men with a recent suicide attempt and the results suggest that suicide attempts may be mediated by different biological variables than aggression.
Journal ArticleDOI
Long-term risk factors for suicide in suicide attempters examined at a medical emergency in patient unit : results from a 32-year follow-up study
TL;DR: The risk of suicide after a suicide attempt persists for up to 32 years after the index attempt and the SIS score is a better predictor of suicide risk at short term, that is, within 5 years than at long term.
Journal ArticleDOI
Suicidal behavior in depression: relationship to platelet serotonin transporter.
TL;DR: Patients who had a lifetime history of a suicide attempt had a significantly greater apparent Michaelis constant (Km) of platelet serotonin uptake than either depressed patients who had never attempted suicide or controls.
Journal ArticleDOI
Caudate nucleus dopamine D(2) receptors in depressed suicide victims.
Per Allard,Maria Norlén +1 more
TL;DR: Previous findings regarding changes in dopamine metabolism in depression and antidepressant effects of dopamine agonists seem, according to the present study, not to be reflected by alterations in density or affinity of dopamine D2 receptors in depressed suicide victims.
References
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Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
A comprehensive psychopathological rating scale.
TL;DR: An interdisciplinary group of 15 psychiatrists, psychologists and clinical pharmacologists was formed under the auspices of the Swedish Medical Research Council to study the problem of evaluating change in psychiatric disorders with treatment and decided to construct a new scale covering psychopathological variables likely to be changed by treatment.