Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
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TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
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Book ChapterDOI
Is Serotonin Involved in the Pathogenesis of Schizophrenia
TL;DR: The antipsychotic potential of 5-HT, receptor antagonists was inferred from animal experiments and the first human data are encouraging, justifying the question whether in schizophrenic patients 5- HT disturbances do occur.
Journal ArticleDOI
A Descriptive Cohort of Suicidal Cancer Patients: Analysis of the Autopsy Case Series from 1993 to 2019 in Milan (Italy)
TL;DR: Assessment of suicides that occurred in cancer patients at the Institute of Forensic Medicine of Milan, Italy found violent suicide methods were prevalent, and the most represented suicide method was falling from height regardless of the body area affected by cancer.
Book ChapterDOI
Depression, Sleep Disorders, and DA
Traci J. Speed,Patrick H. Finan +1 more
TL;DR: It is reasonable to glean from this chapter that a common alteration in mesolimbic dopaminergic signaling pathway underlies the comorbidity of depression, insomnia, and circadian rhythm disorders.
Book ChapterDOI
Past Suicide Attempt and Monoamine Metabolites: Comparing CSF Concentrations and Angularized Ratios
Hans Ågren,Alec Roy +1 more
TL;DR: Results are conflicting, with fairly consistent findings of an assumedly decreased serotonin turnover, i.e., low cerebrospinal fluid (CSF) 5-HIAA, in brains of patients exhibiting violent behaviors.
Odrębności między depresją w chorobie afektywnej dwubiegunowej i jednobiegunowej
TL;DR: A review of the studies comparing unipolar and bipolar depression with focus on the course, symptomatology, neuroscience, and psychosocial literatures is presented in this article with one question in mind: does the evidence support diagnosing bipolar and unipolar depressions as the same disorder or different?
References
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Journal ArticleDOI
5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
Journal ArticleDOI
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