Journal ArticleDOI
Monoamine metabolites in CSF and suicidal behavior.
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TLDR
A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.Abstract:
• Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF 5-HIAA level below the median.read more
Citations
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Journal ArticleDOI
Aggression and suicide attempts: preliminary data
TL;DR: Results showed a significant decrease in the maximum binding capacity of 3H-imipramine binding to platelet membranes in suicide attempters, who also exhibited higher total and single item scores at QTA than healthy controls or depressed patients.
Patent
Method for detecting abnormal serotonergic function
TL;DR: In this article, a method of detecting abnormal serotonergic function in an impulsive human subject is disclosed, which comprises detecting an L allele of a gene encoding tryptophan hydroxylase.
Journal ArticleDOI
Secondary sociopathy and opportunistic reproductive strategy
TL;DR: Mealey's analysis of secondary sociopathy has much in common with Belsky, Steinberg, and Draper's (1991) evolutionary theory of socialization as mentioned in this paper, drawing attention to the potential influence of early rearing in the promotion of a cold, detached, manipulative, and opportunistic style of relating to others.
Book ChapterDOI
Beyond Nosology in Biological Psychiatry. 5-HT Disturbances in Mood, Aggression and Anxiety Disorders
H. M. van Praag,R.S. Kahn,Gregory M. Asnis,Scott Wetzler,Serena-Lynn Brown,Avraham Bleich,Martin L. Korn +6 more
TL;DR: In this paper, the authors discuss the available data, and then they try to bring them into a conceptual framework to explain why 5-HT disorders have been reported in depression, anxiety states, schizophrenia and alcoholism.
Journal ArticleDOI
Clinical and psychometric features of psychiatric patients after a suicide attempt in relation with menstrual cycle phases
Athanasia Papadopoulou,Vasiliki Efstathiou,Christos Christodoulou,Rossetos Gournellis,Charalabos Papageorgiou,Athanassios Douzenis,Manolis Markianos +6 more
TL;DR: Although attempts were unequally distributed during the cycle, none of the psychiatric features assessed in the present study were related to the higher frequency of attempts during premenstrual/ menstrual days, indicating the need to include additional aspects of suicidal behavior in future studies.
References
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Journal ArticleDOI
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Journal ArticleDOI
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